ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
Morphologic and molecular characterization of two novel Krt71 (Krt2-6g) mutations: Krt71rco12 and Krt71rco13.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Polymorphism of Keratin GeneAnimals : an open access journal from MDPI · 2025Article
- Screened of long non-coding RNA related to wool development and fineness in Gansu alpine fine-wool sheep.BMC genomics · 2025Article
- Genome-wide association analysis unveils candidate genes and loci associated with aplasia cutis congenita in pigs.BMC genomics · 2023Article
- Development of Woolly Hair and Hairlessness in a CRISPR-Engineered Mutant Mouse Model with KRT71 Mutations.Cells · 2023Article
- The Mechanisms of Fur Development and Color Formation in American Mink Revealed Using Comparative Transcriptomics.Animals : an open access journal from MDPI · 2022Article
- AGenes · 2021Article
- An epistatic effect of KRT25 on SP6 is involved in curly coat in horses.Scientific reports · 2018Article
- The bald and the beautiful: hairlessness in domestic dog breeds.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.Nature genetics · 2014Article
- CtBP1 overexpression in keratinocytes perturbs skin homeostasis.The Journal of investigative dermatology · 2014Article
- Insights into morphology and disease from the dog genome project.Annual review of cell and developmental biology · 2014Review
- A splice variant in KRT71 is associated with curly coat phenotype of Selkirk Rex cats.Scientific reports · 2013Article
- Hairless plays a role in formation of inner root sheath via regulation of Dlx3 gene.The Journal of biological chemistry · 2012Article
- Gene expression profile of the skin in the 'hairpoor' (HrHp) mice by microarray analysis.BMC genomics · 2010Article
- The naked truth: Sphynx and Devon Rex cat breed mutations in KRT71.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture.American journal of human genetics · 2010Article
- Canine morphology: hunting for genes and tracking mutations.PLoS biology · 2010Article
- Man's best friend becomes biology's best in show: genome analyses in the domestic dog.Annual review of genetics · 2010Review
- Coat variation in the domestic dog is governed by variants in three genes.Science (New York, N.Y.) · 2009Article
- Selkirk Rex: morphological and genetic characterization of a new cat breed.The Journal of heredityArticle
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have analyzed two novel mouse mutant strains, Rco12 and Rco13, displaying a wavy pelage and curly vibrissae that have been identified in an ENU screen for dominant mutations affecting the pelage. The mutations were mapped to mouse Chromosome 15 and identified as missense point mutations in the first exon of the Krt71 (formerly called Krt2-6g) gene causing alterations of amino acid residue 143 from alanine to glycine (Rco12) and residue 146 from isoleucine to phenylalanine. The morphologic analyses demonstrated that both mutations cause identical phenotypes leading to the formation of filamentous aggregates in Henle's and Huxley's layers of the inner root sheath (IRS) of the hair follicle that leads to the bending of the hair shaft. Both novel mutations are located in the immediate vicinity of previously identified mutations in murine Krt71 that cause similar phenotypes and alter the helix initiation motif of the keratin. The characterization of these mutants demonstrates the importance of this Krt71 domain for the formation of linear IRS intermediate filaments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.