SynthesisEuropean archives of psychiatry and clinical neuroscience2006
Is there evidence for negative effects of antidepressants on suicidality in depressive patients? A systematic review.
Synthesis in European archives of psychiatry and clinical neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Evidence for beneficial effects of antidepressants on suicidality in depressive patients: a systematic review.European archives of psychiatry and clinical neuroscience · 2006Pooled it
- A Randomized Clinical Trial Comparing Two Treatment Strategies, Evaluating the Meaningfulness of HAM-D Rating Scale in Patients With Major Depressive Disorder.Frontiers in psychiatry · 2022Article
- The Toxicity Potential of Antidepressants and Antipsychotics in Relation to Other Medication and Alcohol: A Naturalistic and Retrospective Study.Frontiers in psychiatry · 2022Article
- Catalytic Reaction Model of Suicide.Frontiers in psychiatry · 2022Review
- Bipolar depression: a major unsolved challenge.International journal of bipolar disorders · 2020Review
- Toxicological findings in suicides - frequency of antidepressant and antipsychotic substances.Forensic science, medicine, and pathology · 2019Article
- Suicidal Ideation and Suicidal Behavior as Rare Adverse Events of Antidepressant Medication: Current Report from the AMSP Multicenter Drug Safety Surveillance Project.The international journal of neuropsychopharmacology · 2018Article
- Availability of mental health service providers and suicide rates in Slovenia: a nationwide ecological study.Croatian medical journal · 2013Article
- Article
- Antidepressant Utilization and Suicide in Europe: An Ecological Multi-National Study.PloS one · 2013Article
- Experiences from consumer reports on psychiatric adverse drug reactions with antidepressant medication: a qualitative study of reports to a consumer association.BMC pharmacology & toxicology · 2012Article
- General and comparative efficacy and effectiveness of antidepressants in the acute treatment of depressive disorders: a report by the WPA section of pharmacopsychiatry.European archives of psychiatry and clinical neuroscience · 2011Article
- Antidepressant-induced suicidality: an update.CNS neuroscience & therapeutics · 2010Review
- Do SSRIs or antidepressants in general increase suicidality? WPA Section on Pharmacopsychiatry: consensus statement.European archives of psychiatry and clinical neuroscience · 2008Review
- Frequency of different anti-depressants associated with suicides and drug deaths.International journal of legal medicine · 2008Article
- White matter hyperintensities and their associations with suicidality in patients with major affective disorders.European archives of psychiatry and clinical neuroscience · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of antidepressants in suicide prevention is a major public health question given the high prevalence of both depression and depression-related suicidality. Therefore all available means should be utilised to clarify the influence of antidepressants on suicidality, especially in view of the ongoing intensive debate about possible suicidality-inducing effects of antidepressants that may outweigh their traditionally hypothesised beneficial effects. This paper gives a systematic and comprehensive review of the empirical data which might indicate that antidepressants have negative effects on suicidality. First, principal methodological issues related to this research question are discussed. Thereafter, the results of controlled trials and epidemiological and cohort studies are presented. Altogether, there seems to be only a small amount of evidence from different research approaches that antidepressants, not only serotonin reuptake inhibitors (SSRIs), might induce, aggravate or increase the risk of suicidal ideation and suicide attempts. As to suicide, there are no hints in this direction. TCAs have a higher risk of fatal outcome in overdose compared to SSRIs, which, in case of mono-intoxication, carry almost no risk of lethal consequences. The ongoing discussion about suicidality-inducing effects should not prevent physicians from prescribing SSRIs and other antidepressants to their patients if they are clinically indicated. However, they should take into account potential risks and manage them by good clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.