ReviewOncogene2006
The Wnt code: cnidarians signal the way.
Review in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
69 citing papers in PubMed.
- Transcriptomic analysis of three annelid species: looking for markers of positional information.BMC genomics · 2026Article
- An Integrated Canonical and Non-Canonical Wnt Signaling Network Controls Early Anterior-Posterior Axis Formation in Sea Urchin Embryos.Journal of developmental biology · 2025Review
- Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.BMC biology · 2024Article
- The origin and evolution of Wnt signalling.Nature reviews. Genetics · 2024Review
- Optical Control of Tissue Regeneration through Photostimulation of Organic Semiconducting Nanoparticles.Advanced healthcare materials · 2022Article
- siRNA-mediated gene knockdown via electroporation in hydrozoan jellyfish embryos.Scientific reports · 2022Article
- Genome-Wide Identification and Expression Profiling of the Wnt Gene Family in Three Rice Planthoppers: Sogatella furcifera, Laodelphax striatellus, and Nilaparvata lugens.Journal of insect science (Online) · 2022Article
- Injury-induced MAPK activation triggers body axis formation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Evolution of Gene Expression across Species and Specialized Zooids in Siphonophora.Molecular biology and evolution · 2022Article
- Genome of the sea anemoneFrontiers in cell and developmental biology · 2022Article
- Hox genes regulate asexual reproductive behavior and tissue segmentation in adult animals.Nature communications · 2021Article
- Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration.Circulation research · 2021Article
- WNT-FRIZZLED-LRP5/6 Signaling Mediates Posterior Fate and Proliferation during Planarian Regeneration.Genes · 2021Article
- FrizzledHandbook of experimental pharmacology · 2021Article
- WNT5B in Physiology and Disease.Frontiers in cell and developmental biology · 2021Review
- Apcdd1 is a dual BMP/Wnt inhibitor in the developing nervous system and skin.Developmental biology · 2020Article
- Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways.Nature communications · 2019Article
- Wnt evolution and function shuffling in liberal and conservative chordate genomes.Genome biology · 2018Article
- Hox and Wnt pattern the primary body axis of an anthozoan cnidarian before gastrulation.Nature communications · 2018Article
- De novo draft assembly of the Botrylloides leachii genome provides further insight into tunicate evolution.Scientific reports · 2018Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cnidarians are the simplest metazoans with a nervous system. They are well known for their regeneration capacity, which is based on the restoration of a signalling centre (organizer). Recent work has identified the canonical Wnt pathway in the freshwater polyp Hydra, where it acts in organizer formation and regeneration. Wnt signalling is also essential for cnidarian embryogenesis. In the sea anemone Nematostella vectensis 11 of the 12 known wnt gene subfamilies were identified. Different wnt genes exhibit serial and overlapping expression domains along the oral-aboral axis of the embryo (the 'wnt code'). This is reminiscent of the hox code (cluster) in bilaterian embryogenesis that is, however, absent in cnidarians. It is proposed that the common ancestor of cnidarians and bilaterians invented a set of wnt genes that patterned the ancient main body axis. Major antagonists of Wnt ligands (e.g. Dkk 1/2/4) that were previously known only from chordates, are also present in cnidarians and exhibit a similar conserved function. The unexpectedly high level of genetic complexity of wnt genes evolved in early multi-cellular animals about 650 Myr ago and suggests a radical expansion of the genetic repertoire, concurrent with the evolution of multi-cellularity and the diversification of eumetazoan body plans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.