ArticleBiophysical journal1991
Diffusion model in ion channel gating. Extension to agonist-activated ion channels.
Article in Biophysical journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Gating of maxi channels observed from pseudo-phase portraits.American journal of physiology. Cell physiology · 2013Article
- Quantitative analysis of DNA-looping kinetics from tethered particle motion experiments.Methods in enzymology · 2010Article
- Single ion channel models incorporating aggregation and time interval omission.Biophysical journal · 1993Article
- Analysis of cyclic and acyclic nicotinic cholinergic agonists using radioligand binding, single channel recording, and nuclear magnetic resonance spectroscopy.Biophysical journal · 1993Article
- Protein dynamics and 1/f noise.Biophysical journal · 1992Article
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Authors and funding
3 authors.
Funding
Abstract
Previously, we described a model which treats ion channel gating as a discrete diffusion problem. In the case of agonist-activated channels at high agonist concentration, the model predicts that the closed lifetime probability density function from single channel recording approximates a power law with an exponent of -3/2 (Millhauser, G. L., E. E. Salpeter, and R. E. Oswald. 1988a. Proc. Natl. Acad. Sci. USA. 85: 1503-1507). This prediction is consistent with distributions derived from a number of ligand-gated channels at high agonist concentration (Millhauser, G. L., E. E. Salpeter, and R. E. Oswald. 1988b. Biophys. J. 54: 1165-1168.) but does not describe the behavior of ion channels at low activator concentrations. We examine here an extension of this model to include an agonist binding step. This extended model is consistent with the closed time distributions generated from the BC3H-1 nicotinic acetylcholine receptor for agonist concentrations varying over three orders of magnitude.
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