ReviewStem cell reviews2005
Leukemic stem cells: where do they come from?
Review in Stem cell reviews, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Assessment of TNF α and IL-6 Levels in Indian Patients of CML and their Correlation with Early Molecular Response: An Observational Study.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Article
- A review on the functional characteristics of the c-Myeloproliferative Leukaemia (c-MPL) gene and its isoforms.Cellular oncology (Dordrecht, Netherlands) · 2024Review
- A concise review of the regulatory, diagnostic, and prognostic implications of HOXB-AS3 in tumors.Journal of Cancer · 2024Review
- CD8Leukemia · 2019Article
- The invasion of de-differentiating cancer cells into hierarchical tissues.PLoS computational biology · 2019Article
- Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells.Nature communications · 2018Article
- Yi-qi-yang-yin-tang increases the sensitivity of KG1a leukemia stem cells to daunorubicin by promoting cell cycle progression and regulating the expression of PTEN, TOPOII and mTOR.Oncology letters · 2017Article
- Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science.Biotechnology journal · 2015Review
- C/EBPβ promotes BCR-ABL-mediated myeloid expansion and leukemic stem cell exhaustion.Leukemia · 2013Article
- Article
- IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development.Cancer cell · 2011Article
- Transcriptome profiling and sequencing of differentiated human hematopoietic stem cells reveal lineage-specific expression and alternative splicing of genes.Physiological genomics · 2011Article
- The Role of MicroRNAs in Hematopoietic Stem Cell and Leukemic Stem Cell Function.Therapeutic advances in hematology · 2011Article
- Transcriptional and epigenetic regulation of B cell development.Immunologic research · 2011Review
- Prostate cancer stem cells.Central European journal of urology · 2011Review
- p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.Genes & development · 2010Article
- Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia.British journal of cancer · 2009Article
- Epigenetic gene regulation in stem cells and correlation to cancer.Differentiation; research in biological diversity · 2009Review
- Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice.Genes & development · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Leukemias can now be viewed as aberrant hematopoietic processes initiated by rare cancer stem cells, or leukemic stem cells (LSCs) that have maintained or reacquired the capacity for indefinite proliferation through accumulated mutations and/or epigenetic changes. Yet, despite their critical importance, much remains to be learned about the developmental origin of LSCs and the mechanisms responsible for their emergence in the course of the disease. Mouse models of human leukemias have provided a unique system to study the mechanisms influencing LSC generation and function, and were recently used to demonstrate that LSCs can arise from both self-renewing hematopoietic stem cells (HSCs) and committed progenitor populations. This striking finding indicates that LSC identity is largely dictated by the nature of the oncogenic events and by how these events perturb essential processes such as self-renewal, proliferation, differentiation, and survival. Such approaches in the mouse are essential for the basic understanding of leukemogenesis and for the conceptual design of novel therapeutic strategies that could lead to improved treatments for human leukemias.
Indexed as
Identifiers
17142854What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.