ReviewStem cell reviews2005
Human embryonic stem cells: an in vitro model to study mechanisms controlling pluripotency in early mammalian development.
Review in Stem cell reviews, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Cultured chicken meat developed by structuring cellular spheroids on an edible bacterial nanocellulose bioscaffold.NPJ science of food · 2025Article
- Challenges Facing the Translation of Embryonic Stem Cell Therapy for the Treatment of Cartilage Lesions.Stem cells translational medicine · 2022Review
- The specialized mitotic behavior of human embryonic stem cells.Cell and tissue research · 2022Article
- Healing of bone defects by induced pluripotent stem cell-derived bone marrow mesenchymal stem cells seeded on hydroxyapatite-zirconia.Annals of translational medicine · 2021Article
- Role of miRNA-mRNA Interaction in Neural Stem Cell Differentiation of Induced Pluripotent Stem Cells.International journal of molecular sciences · 2020Article
- Astrocytes in a dish: Using pluripotent stem cells to model neurodegenerative and neurodevelopmental disorders.Brain pathology (Zurich, Switzerland) · 2017Article
- Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG).Molecular & cellular proteomics : MCP · 2016Article
- Spheroid Culture of Mesenchymal Stem Cells.Stem cells international · 2016Review
- GDF10 is a signal for axonal sprouting and functional recovery after stroke.Nature neuroscience · 2015Article
- From pluripotency to forebrain patterning: an in vitro journey astride embryonic stem cells.Cellular and molecular life sciences : CMLS · 2014Review
- Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Small molecule mesengenic induction of human induced pluripotent stem cells to generate mesenchymal stem/stromal cells.Stem cells translational medicine · 2012Article
- Deep-transcriptome and ribonome sequencing redefines the molecular networks of pluripotency and the extracellular space in human embryonic stem cells.Genome research · 2011Article
- Ethanol, acetaldehyde, and estradiol affect growth and differentiation of rhesus monkey embryonic stem cells.Alcoholism, clinical and experimental research · 2011Article
- Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Quantitative top-down proteomics of SILAC labeled human embryonic stem cells.Journal of the American Society for Mass Spectrometry · 2010Article
- Small molecules and stem cells. Potency and lineage commitment: the new quest for the fountain of youth.Journal of medicinal chemistry · 2010Review
- Dynamic 3D culture promotes spontaneous embryonic stem cell differentiation in vitro.Tissue engineering. Part C, Methods · 2010Article
- Tumour formation by single fibroblast growth factor receptor 3-positive rhabdomyosarcoma-initiating cells.British journal of cancer · 2009Article
- Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery.PloS one · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The property of pluripotency confers the capacity for differentiation into a large number of cell types including extra-embryonic, somatic and germinal cells. During normal development, pluripotency is acquired by the cells of the early embryo, which shortly thereafter undergo differentiation, whereas embryonic stem cells (ESCs) uniquely maintain pluripotency while undergoing extensive in vitro proliferation. Studies using ESCs have begun to unravel the network of cytokines and transcription factors responsible for their maintenance of pluripotency. Surprisingly, mouse and human ESCs display significant differences in such mechanisms despite their similar embryonic origins. In this review, we compare the properties of pluripotent embryonic cells with those of ESCs to establish a general model for the mechanisms maintaining pluripotency. We first consider whether mouse and human ESCs represent comparable stages of early embryonic development. We then describe how human embryoid body (EB) differentiation could be used as a model of embryonic development. Finally, to concretely illustrate the discussion, we discuss our recent results concerning Nodal function in controlling cell fate at early stages of human EB development. With the new perspective of these findings, we suggest a previously unrecognized role of TGF-beta pathway signaling in maintaining pluripotency at early stages of mammalian embryonic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.