ArticleJournal of immunology (Baltimore, Md. : 1950)2006
Biomechanical signals suppress proinflammatory responses in cartilage: early events in experimental antigen-induced arthritis.
Article in Journal of immunology (Baltimore, Md. : 1950), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Peripheral and central changes induced by neural mobilization in animal models of neuropathic pain: a systematic review.Frontiers in neurology · 2023Pooled it
- Vocal exercise may attenuate acute vocal fold inflammation.Journal of voice : official journal of the Voice Foundation · 2012Trial
- Microphysiological System-Generated Physiological Shear Forces Reduce TNF-α-Mediated Cartilage Damage in a 3D Model of Arthritis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mitigating the Effects of Acute Vocal Exertion in Individuals With Vocal Fatigue.The Laryngoscope · 2021Article
- Restoration Strategies Following Short-Term Vocal Exertion in Healthy Young Adults.Journal of speech, language, and hearing research : JSLHR · 2021Article
- Physiological Responses Induced by Manual Therapy in Animal Models: A Scoping Review.Frontiers in neuroscience · 2020Article
- Insulin Resistance in Osteoarthritis: Similar Mechanisms to Type 2 Diabetes Mellitus.Journal of nutrition and metabolism · 2020Review
- Effects of Inflammation on Multiscale Biomechanical Properties of Cartilaginous Cells and Tissues.ACS biomaterials science & engineering · 2017Review
- Manual therapy and eccentric exercise in the management of Achilles tendinopathy.The Journal of manual & manipulative therapy · 2017Article
- Exercise-driven metabolic pathways in healthy cartilage.Osteoarthritis and cartilage · 2016Article
- Arthroscopic partial anterior synovectomy of the knee on patients with haemophilia.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Article
- The regional sensitivity of chondrocyte gene expression to coactive mechanical load and exogenous TNF-α stimuli.Journal of biomechanical engineering · 2014Article
- Mechanical loading: potential preventive and therapeutic strategy for osteoarthritis.The Journal of the American Academy of Orthopaedic Surgeons · 2014Article
- High resolution micro arthrography of hard and soft tissues in a murine model.Osteoarthritis and cartilage · 2012Article
- Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation.Pathobiology of aging & age related diseases · 2012Article
- Mechanical loading: bone remodeling and cartilage maintenance.Current osteoporosis reports · 2011Review
- Mechanotransduction and cartilage integrity.Annals of the New York Academy of Sciences · 2011Review
- Biological basis of exercise-based treatments for musculoskeletal conditions.PM & R : the journal of injury, function, and rehabilitation · 2011Review
- Transcriptome-wide gene regulation by gentle treadmill walking during the progression of monoiodoacetate-induced arthritis.Arthritis and rheumatism · 2011Article
- Physiological loading of joints prevents cartilage degradation through CITED2.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Although biomechanical signals generated during joint mobilization are vital in maintaining integrity of inflamed cartilage, the molecular mechanisms of their actions are little understood. In an experimental model of arthritis, we demonstrate that biomechanical signals are potent anti-inflammatory signals that repress transcriptional activation of proinflammatory genes and augment expression of anti-inflammatory cytokine IL-10 to profoundly attenuate localized joint inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.