ArticlePlant physiology2007
Cell death suppressor Arabidopsis bax inhibitor-1 is associated with calmodulin binding and ion homeostasis.
Article in Plant physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
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- Plastid methylerythritol phosphate pathway participates in the hypersensitive response-related cell death inFrontiers in plant science · 2022Article
- Calmodulin7: recent insights into emerging roles in plant development and stress.Plant molecular biology · 2021Review
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- The Arabidopsis thaliana gene AtERF019 negatively regulates plant resistance to Phytophthora parasitica by suppressing PAMP-triggered immunity.Molecular plant pathology · 2020Article
- Arabidopsis GAAPs interacting with MAPR3 modulate the IRE1-dependent pathway upon endoplasmic reticulum stress.Journal of experimental botany · 2019Article
- Arabidopsis Bax inhibitor-1 interacts with enzymes related to very-long-chain fatty acid synthesis.Journal of plant research · 2019Article
- The Wheat Bax Inhibitor-1 Protein Interacts with an Aquaporin TaPIP1 and Enhances Disease Resistance inFrontiers in plant science · 2018Article
- Plant Bax Inhibitor-1 interacts with ATG6 to regulate autophagy and programmed cell death.Autophagy · 2017Article
- TMBIM-mediated CaBiochimica et biophysica acta. Molecular cell research · 2017Review
- Unravelling Protein-Protein Interaction Networks Linked to Aliphatic and Indole Glucosinolate Biosynthetic Pathways in Arabidopsis.Frontiers in plant science · 2017Article
- Expression of Arabidopsis Bax Inhibitor-1 in transgenic sugarcane confers drought tolerance.Plant biotechnology journal · 2016Article
- Transcriptomic and physiological analysis of common duckweed Lemna minor responses to NH4(+) toxicity.BMC plant biology · 2016Article
- Transcriptome dynamics of a susceptible wheat upon Fusarium head blight reveals that molecular responses to Fusarium graminearum infection fit over the grain development processes.Functional & integrative genomics · 2016Article
- Overexpression of BAX INHIBITOR-1 Links Plasma Membrane Microdomain Proteins to Stress.Plant physiology · 2015Article
- Article
- Structural basis for a pH-sensitive calcium leak across membranes.Science (New York, N.Y.) · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell death suppressor Bax inhibitor-1 (BI-1), an endoplasmic reticulum membrane protein, exists in a wide range of organisms. The split-ubiquitin system, overlay assay, and bimolecular fluorescence complementation analysis demonstrated that Arabidopsis (Arabidopsis thaliana) BI-1 (AtBI-1) interacted with calmodulin in yeast (Saccharomyces cerevisiae) and in plant cells. Furthermore, AtBI-1 failed to rescue yeast mutants lacking Ca2+ ATPase (Pmr1 or Spf1) from Bax-induced cell death. Pmr1 and Spf1, p-type ATPases localized at the inner membrane, are believed to be involved in transmembrane movement of calcium ions in yeast. Thus, the presence of intact Ca2+ ATPases was essential for AtBI-1-mediated cell death suppression in yeast. To investigate the effect of AtBI-1 on calcium homeostasis, we evaluated sensitivity against cyclopiazonic acid (CPA), an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase in AtBI-1-overexpressing or knock-down transgenic Arabidopsis plants. These plants demonstrated altered CPA or ion stress sensitivity. Furthermore, AtBI-1-overexpressing cells demonstrated an attenuated rise in cytosolic calcium following CPA or H2O2 treatment, suggesting that AtBI-1 affects ion homeostasis in plant cell death regulation.
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