ArticleJournal of bacteriology2007
Transcriptomic analysis reveals a bifurcated terephthalate degradation pathway in Rhodococcus sp. strain RHA1.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 107 citations in OpenAlex.
- Biodegradation and metabolic assimilation of poly (butylene adipate-co-terephthalate) (PBAT) by Gordonia sp. CN2K.Biodegradation · 2026Article
- A novel phthalic acid degradation pathway in Klebsiella variicola SY1 and engineering the strain for degradation of multiple phthalate esters.World journal of microbiology & biotechnology · 2026Article
- Elucidating biodegradation of dimethyl terephthalate by twoMetabolic engineering communications · 2026Article
- High-load terephthalic acid degradation and diverse bioproduct formation by novel Rhodococcus strains.Biotechnology letters · 2026Article
- Genetically encoded biosensor enabled mining, characterisation and engineering of aromatic acid MFS transporters.Journal of biological engineering · 2025Article
- Genetic Bioaugmentation-Mediated Bioremediation of Terephthalate in Soil Microcosms Using an Engineered Environmental Plasmid.Microbial biotechnology · 2025Article
- Cross-feeding drives degradation of phthalate ester plasticizers in a bacterial consortium.Frontiers in microbiology · 2025Article
- A mycofactocin-associated dehydrogenase is essential for ethylene glycol metabolism by Rhodococcus jostii RHA1.Applied microbiology and biotechnology · 2024Article
- Bacterial Catabolism of Phthalates With Estrogenic Activity Used as Plasticisers in the Manufacture of Plastic Products.Microbial biotechnology · 2024Review
- The catabolism of ethylene glycol byApplied and environmental microbiology · 2024Article
- Mechanisms and high-value applications of phthalate isomers degradation pathways in bacteria.World journal of microbiology & biotechnology · 2024Review
- Novel aspects of ethylene glycol catabolism.Applied microbiology and biotechnology · 2024Review
- Assimilation of phthalate esters in bacteria.Applied microbiology and biotechnology · 2024Review
- Article
- Article
- Exploring Microorganisms from Plastic-Polluted Sites: Unveiling Plastic Degradation and PHA Production Potential.Microorganisms · 2023Article
- Coexistence of specialist and generalist species within mixed plastic derivative-utilizing microbial communities.Microbiome · 2023Article
- Poly(butylene adipate-co-terephthalate) biodegradation by Purpureocillium lilacinum strain BA1S.Applied microbiology and biotechnology · 2023Article
- Engineering microbial division of labor for plastic upcycling.Nature communications · 2023Article
- Versatile microbial communities rapidly assimilate ammonium hydroxide-treated plastic waste.Journal of industrial microbiology & biotechnology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phthalate isomers and their esters are important pollutants whose biodegradation is not well understood. Rhodococcus sp. strain RHA1 is notable for its ability to degrade a wide range of aromatic compounds. RHA1 was previously shown to degrade phthalate (PTH) and to have genes putatively encoding terephthalate (TPA) degradation. Transcriptomic analysis of 8,213 genes indicated that 150 were up-regulated during growth on PTH and that 521 were up-regulated during growth on TPA. Distinct ring cleavage dioxygenase systems were differentially expressed during growth on PTH and TPA. Genes encoding the protocatechuate (PCA) pathway were induced on both substrates, while genes encoding the catechol branch of the PCA pathway were additionally induced only on TPA. Accordingly, protocatechuate-3,4-dioxygenase activity was induced in cells grown on both substrates, while catechol-1,2-dioxygenase activity was induced only in cells grown on TPA. Knockout analysis indicated that pcaL, encoding 3-oxoadipate enol-lactone hydrolase and 4-carboxymuconolactone decarboxylase, was required for growth on both substrates but that pcaB, encoding beta-carboxy-cis,cis-muconate lactonizing enzyme, was required for growth on PTH only. These results indicate that PTH is degraded solely via the PCA pathway, whereas TPA is degraded via a bifurcated pathway that additionally includes the catechol branch of the PCA pathway.
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