ArticleAnnals of the rheumatic diseases2007
Arthritis of the large joints - in particular, the knee - at first presentation is predictive for a high level of radiological destruction of the small joints in rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Evolving role of FDG PET imaging in assessing joint disorders: a systematic review.European journal of nuclear medicine and molecular imaging · 2011Pooled it
- Trial
- Using machine learning to uncover joint involvement patterns linked to disease activity and disability in rheumatoid arthritis.Clinical rheumatology · 2026Article
- ASIA syndrome after BNT162b2 vaccination: Is it a distinct rheumatoid arthritis phenotype?Immunologic research · 2024Article
- Effects of IL-6, JAK, TNF inhibitors, and CTLA4-Ig on knee symptoms in patients with rheumatoid arthritis.Scientific reports · 2024Article
- The first involved joints and associated factors in patients with rheumatoid arthritis.Archives of rheumatology · 2024Article
- [A cross-sectional study on the clinical phenotypes of rheumatoid arthritis].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
- Large joints are progressively involved in rheumatoid arthritis irrespective of rheumatoid factor status-results from the early rheumatoid arthritis study.Rheumatology international · 2022Article
- Comparison of efficacy between anti-IL-6 receptor antibody and other biological disease-modifying antirheumatic drugs in the patients with rheumatoid arthritis who have knee joint involvement: the ANSWER cohort, retrospective study.Rheumatology international · 2021Article
- B Cell Synovitis and Clinical Phenotypes in Rheumatoid Arthritis: Relationship to Disease Stages and Drug Exposure.Arthritis & rheumatology (Hoboken, N.J.) · 2020Article
- Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC).Annals of the rheumatic diseases · 2019Article
- Patients with Rheumatoid Arthritis Were Associated with a Risk of Rotator Cuff Diseases.Journal of clinical medicine · 2019Article
- Can Synovial Pathobiology Integrate with Current Clinical and Imaging Prediction Models to Achieve Personalized Health Care in Rheumatoid Arthritis?Frontiers in medicine · 2017Review
- Current imaging strategies in rheumatoid arthritis.American journal of nuclear medicine and molecular imaging · 2012Article
- Radiographic estimation in seropositive and seronegative rheumatoid arthritis.Bosnian journal of basic medical sciences · 2011Article
- The relationship between the presence of anti-cyclic citrullinated peptide antibodies and clinical phenotype in very early rheumatoid arthritis.BMC musculoskeletal disorders · 2010Article
- Enhanced MRI in early undifferentiated oligoarthritis of the knee joints: improvements already visible after 2 months of DMARDs treatment.Clinical rheumatology · 2008Article
- The role of anti-cyclic cytrullinate antibodies testing in rheumatoid arthritis.Clinical reviews in allergy & immunology · 2008Review
- Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure.Arthritis research & therapy · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the predictive value of the distribution of inflamed joints at first presentation for the severity of the disease course in rheumatoid arthritis (RA).
methodsOf the 1009 consecutive patients included in the Leiden Early Arthritis Clinic (Leiden, The Netherlands), 285 patients fulfilled the American College of Rheumatology criteria for RA within 1 year of follow-up. Of these, 28 patients achieved remission. Radiographs of hands and feet were scored according to the Sharp-van der Heijde method, and the 28 patients with the most destructive disease were selected. The distribution of inflamed joints of the patients with the extreme disease courses was compared. The association between the distribution of inflamed joints and the level of destruction of the joints of hands and feet in the whole group of patients with RA was assessed using regression analysis.
resultsComparison of patients with extreme disease courses using univariate and logistic regression analyses showed that arthritis of the large joints - in particular, the knee - was associated with severe RA. In the whole group of patients with RA, the total number of swollen joints and the presence of knee arthritis were associated independently with the level of destruction of the small joints. Patients with RA with knee arthritis had higher C reactive protein (CRP) levels than patients without knee arthritis, and investigating the distribution of inflamed joints together with other variables yielded the number of swollen joints, CRP, presence of anti-cyclic citrullinated peptide antibodies and symptom duration as predictors for severity of RA.
conclusionArthritis of large joints - in particular, the knee - at first presentation is associated with a destructive course of RA.
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