ArticleBiophysical journal2007
Forces applied by cilia measured on explants from mucociliary tissue.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Advances in high-resolution imaging of centrioles and cilia.Journal of cell science · 2025Review
- Phase-resolved dynamic wavefront imaging of cilia metachronal waves.Quantitative imaging in medicine and surgery · 2023Article
- Physiology and pathophysiology of human airway mucus.Physiological reviews · 2022Review
- Materials science and mechanosensitivity of living matter.Applied physics reviews · 2022Review
- Rheological analysis of sputum from patients with chronic bronchial diseases.Scientific reports · 2020Article
- How Does Cilium Length Affect Beating?Biophysical journal · 2019Article
- Three-dimensional tracking of microbeads attached to the tip of single isolated tracheal cilia beating under external load.Scientific reports · 2018Article
- Seeing cilia: imaging modalities for ciliary motion and clinical connections.American journal of physiology. Lung cellular and molecular physiology · 2018Review
- An autocrine ATP release mechanism regulates basal ciliary activity in airway epithelium.The Journal of physiology · 2017Article
- A new index for characterizing micro-bead motion in a flow induced by ciliary beating: Part I, experimental analysis.PLoS computational biology · 2017Article
- Biophysical differences between chronic myelogenous leukemic quiescent and proliferating stem/progenitor cells.Nanomedicine : nanotechnology, biology, and medicine · 2016Article
- A computational model of dynein activation patterns that can explain nodal cilia rotation.Biophysical journal · 2015Article
- Abnormal nasal nitric oxide production, ciliary beat frequency, and Toll-like receptor response in pulmonary nontuberculous mycobacterial disease epithelium.American journal of respiratory and critical care medicine · 2013Article
- Quantitative study of the elastic modulus of loosely attached cells in AFM indentation experiments.Biophysical journal · 2013Article
- Will the rod bend or break? Analyzing the structural resilience of cellular organelles.Biophysical journal · 2013Article
- Modeling the flexural rigidity of rod photoreceptors.Biophysical journal · 2013Article
- Force generation and dynamics of individual cilia under external loading.Biophysical journal · 2010Article
- The forces applied by cilia depend linearly on their frequency due to constant geometry of the effective stroke.Biophysical journal · 2008Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Forces applied by intact mucus-propelling cilia were measured for the first time that we know of using a combined atomic force microscopy (AFM) and electrooptic system. The AFM probe was dipped into a field of beating cilia and its time-dependent deflection was recorded as it was struck by the cilia while the electrooptic system simultaneously and colocally measured the frequency to ensure that no perturbation was induced by the AFM probe. Using cilia from frog esophagus, we measured forces of approximately 0.21 nN per cilium during the effective stroke. This value, together with the known internal structure of these cilia, leads to the conclusion that most dynein arms along the length of the axoneme contribute to the effective stroke of these cilia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.