ArticleBiophysical journal2007
Characterization of physical properties of supported phospholipid membranes using imaging ellipsometry at optical wavelengths.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- CD39 mRNA therapy attenuates localized acute inflammation: A novel anti-inflammatory strategy using cationic nanoliposomes.Molecular therapy. Nucleic acids · 2026Article
- Advancements in Engineering Planar Model Cell Membranes: Current Techniques, Applications, and Future Perspectives.Nanomaterials (Basel, Switzerland) · 2024Review
- A Label-Free Multitechnique Approach to Characterize the Interaction of Bioactive Compounds with Biomimetic Interfaces.Small science · 2024Article
- Interleaflet Decoupling in a Lipid Bilayer at Excess Cholesterol Probed by Spectroscopic Ellipsometry and Simulations.The Journal of membrane biology · 2020Article
- Visualization and measurement of the local absorption coefficients of single bilayer phospholipid membranes using scanning near-field optical microscopy.Biomedical optics express · 2019Article
- Impact of Quantum Dot Surface on Complex Formation with Chlorin e₆ and Photodynamic Therapy.Nanomaterials (Basel, Switzerland) · 2018Article
- Biophysical Characterization of Supported Lipid Bilayers Using Parallel Dual-Wavelength Surface Plasmon Resonance and Quartz Crystal Microbalance Measurements.Langmuir : the ACS journal of surfaces and colloids · 2018Article
- Label-free and charge-sensitive dynamic imaging of lipid membrane hydration on millisecond time scales.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Surface Charge and Overlayer pH Influence the Dynamics of Supported Phospholipid Films.Journal of electroanalytical chemistry (Lausanne, Switzerland) · 2018Article
- Microwave measurement of giant unilamellar vesicles in aqueous solution.Scientific reports · 2018Article
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- Article
- Dynamic label-free imaging of lipid nanodomains.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Watching individual molecules flex within lipid membranes using SERS.Scientific reports · 2014Article
- Biomimetic silica microspheres in biosensing.Molecules (Basel, Switzerland) · 2010Review
- An ion-channel-containing model membrane: structural determination by magnetic contrast neutron reflectometry.Soft matter · 2009Article
- Evidence for leaflet-dependent redistribution of charged molecules in fluid supported phospholipid bilayers.Langmuir : the ACS journal of surfaces and colloids · 2008Article
- Multiplexing ligand-receptor binding measurements by chemically patterning microfluidic channels.Analytical chemistry · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Subnanometer-scale vertical z-resolution coupled with large lateral area imaging, label-free, noncontact, and in situ advantages make the technique of optical imaging ellipsometry (IE) highly suitable for quantitative characterization of lipid bilayers supported on oxide substrates and submerged in aqueous phases. This article demonstrates the versatility of IE in quantitative characterization of structural and functional properties of supported phospholipid membranes using previously well-characterized examples. These include 1), a single-step determination of bilayer thickness to 0.2 nm accuracy and large-area lateral uniformity using photochemically patterned single 1,2-dimyristoyl-sn-glycero-3-phosphocholine bilayers; 2), hydration-induced spreading kinetics of single-fluid 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine bilayers to illustrate the in situ capability and image acquisition speed; 3), a large-area morphological characterization of phase-separating binary mixtures of 1,2-dilauroyl-sn-glycero-3-phosphocholine and galactosylceramide; and 4), binding of cholera-toxin B subunits to GM1-incorporating bilayers. Additional insights derived from these ellipsometric measurements are also discussed for each of these applications. Agreement with previous studies confirms that IE provides a simple and convenient tool for a routine, quantitative characterization of these membrane properties. Our results also suggest that IE complements more widely used fluorescence and scanning probe microscopies by combining large-area measurements with high vertical resolution without the use of labeled lipids.
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