ArticleParasitology2007
Characterization and application of multiple genetic markers for Plasmodium malariae.
Article in Parasitology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Genetic polymorphism and natural selection of apical membrane antigen-1 in Plasmodium malariae isolated from Vietnam.BMC infectious diseases · 2026Article
- Plasmodium malariae is an overlooked malaria parasite with emerging challenges.Communications medicine · 2026Review
- Metagenomic complexity of high, seasonal transmission of Plasmodium spp. in asymptomatic carriers in Northern Sahelian Ghana.Communications medicine · 2025Article
- Metagenomic analysis reveals extreme complexity ofmedRxiv : the preprint server for health sciences · 2025Article
- Genetic diversity ofFrontiers in cellular and infection microbiology · 2024Article
- Selective whole genome amplification of Plasmodium malariae DNA from clinical samples reveals insights into population structure.Scientific reports · 2020Article
- Polymorphic markers for identification of parasite population in Plasmodium malariae.Malaria journal · 2020Article
- A case of Plasmodium malariae recurrence: recrudescence or reinfection?Malaria journal · 2019Review
- Molecular approaches to determine the multiplicity of Plasmodium infections.Malaria journal · 2018Review
- A bite to fight: front-line innate immune defenses against malaria parasites.Pathogens and global health · 2018Review
- Genetic diversity of three surface protein genes in Plasmodium malariae from three Asian countries.Malaria journal · 2018Article
- Species and genotype diversity of Plasmodium in malaria patients from Gabon analysed by next generation sequencing.Malaria journal · 2017Article
- Molecular characterization and phylogenetic analysis ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2017Article
- Can Mixed Parasite Infections Thwart Targeted Malaria Elimination Program in India?BioMed research international · 2017Article
- Limited Polymorphism of the Kelch Propeller Domain in Plasmodium malariae and P. ovale Isolates from Thailand.Antimicrobial agents and chemotherapy · 2016Article
- Genotypic diversity and spatial-temporal distribution of Symbiodinium clones in an abundant reef coral.Molecular ecology · 2011Article
- Comparative population structure of Plasmodium malariae and Plasmodium falciparum under different transmission settings in Malawi.Malaria journal · 2011Article
- Detecting number of clones, and their relative abundance, of a malaria parasite (Plasmodium mexicanum) infecting its vertebrate host.Parasitology research · 2009Article
- Effect of transmission setting and mixed species infections on clinical measures of malaria in Malawi.PloS one · 2008Article
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4 authors.
Funding
Abstract
Plasmodium malariae, a protozoan parasite that causes malaria in humans, has a global distribution in tropical and subtropical regions and is commonly found in sympatry with other Plasmodium species of humans. Little is known about the genetics or population structure of P. malariae. In the present study, we describe polymorphic genetic markers for P. malariae and present the first molecular epidemiological data for this parasite. Six microsatellite or minisatellite markers were validated using 76 P. malariae samples from a diverse geographical range. The repeat unit length varied from 2 to 17 bp, and up to 10 different alleles per locus were detected. Multiple genotypes of P. malariae were detected in 33 of 70 samples from humans with naturally acquired infection. Heterozygosity was calculated to be between 0.236 and 0.811. Allelic diversity was reduced for samples from South America and, at some loci, in samples from Thailand compared with those from Malawi. The number of unique multilocus genotypes defined using the 6 markers was significantly greater in Malawi than in Thailand, even when data from single genotype infections were used. There was a significant reduction in the multiplicity of infection in symptomatic infections compared with asymptomatic ones, suggesting that clinical episodes are usually caused by the expansion of a single genotype.
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