ArticleCardiovascular diabetology2006
The association of metabolic syndrome and Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, and herpes simplex virus type 1: the Persian Gulf Healthy Heart Study.
Article in Cardiovascular diabetology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions.Scientific reports · 2019Pooled it
- Helicobacter pylori infections in Ethiopia; prevalence and associated factors: a systematic review and meta-analysis.BMC gastroenterology · 2019Pooled it
- Association between herpes simplex virus infection and cardiometabolic diseases: protocol for a systematic review and meta-analysis.BMJ open · 2026Article
- Association between infection with Helicobacter pylori and metabolic syndrome among diabetic patients attending Jimma medical center in Jimma city, Ethiopia: a cross-sectional study.BMC infectious diseases · 2024Article
- Triple therapy for Helicobacter pylori eradication and the risk of hypoglycemia in patients with diabetes: a population-based cohort study.BMC public health · 2023Article
- Acute murine cytomegalovirus infection boosts cell-type specific response and lipid metabolism changes in the liver of infant mice.Frontiers in immunology · 2023Article
- The association ofHeliyon · 2022Article
- The role of pathogens in diabetes pathogenesis and the potential of immunoproteomics as a diagnostic and prognostic tool.Frontiers in microbiology · 2022Review
- Gut Microbiota: The Missing Link BetweenFrontiers in endocrinology · 2021Review
- Positive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population: A Multicenter Nationwide Study.Digestive diseases and sciences · 2019Article
- Is early life exposure to polyomaviruses and herpesviruses associated with obesity indices and metabolic traits in childhood?International journal of obesity (2005) · 2018Article
- Threats to Belonging, Immune Function, and Eating Behavior: an Examination of Sex and Gender Differences.Current psychiatry reports · 2018Review
- Helicobacter pylori infection, gestational diabetes mellitus and insulin resistance among pregnant Sudanese women.BMC research notes · 2018Article
- Relationships of H. pylori infection and its related gastroduodenal morbidity with metabolic syndrome: a large cross-sectional study.Scientific reports · 2018Article
- Effect ofGastroenterology and hepatology from bed to bench · 2016Article
- Review
- No association between Helicobacter pylori infection and diabetes mellitus among a general Japanese population: a cross-sectional study.SpringerPlus · 2015Article
- Intravenous Mycobacterium Bovis Bacillus Calmette-Guérin Ameliorates Nonalcoholic Fatty Liver Disease in Obese, Diabetic ob/ob Mice.PloS one · 2015Article
- Association of helicobacter pylori infection with type 2 diabetes.Indian journal of endocrinology and metabolism · 2014Article
- Association between Hepatitis B Surface Antigen Seropositivity and Metabolic Syndrome.Korean journal of family medicine · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe metabolic syndrome together with insulin resistance and their consequences are basic factors in pathogenesis of atherosclerosis. Chronic infections with herpes simplex virus type 1 (HSV-1), cytomegalovirus (CMV), and Chlamydia pneumoniae are associated with the development of atherosclerosis and coronary heart disease. The infectious aspects of metabolic syndrome have not been investigated.
methodsIn a cross-sectional, population-based study, we used National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP)-III criteria in 1791 subjects, aged 25 years and over, selected by cluster random sampling in three Iranian ports in the northern Persian Gulf. Sera were analyzed for IgG antibodies to Chlamydia pneumoniae, HSV-1, Helicobacter pylori (H. pylori) and CMV using ELISA.
resultsIn multiple logistic regression analysis, of the infectious agents, CMV [OR = 1.81 (1.05-3.10); p = 0.03], H. pylori [OR = 1.50 (1.12-2.00); p = 0.007] and Chlamydia pneumoniae [OR = 1.69 (1.27-2.25); p < 0.0001] showed a significant association with the metabolic syndrome in men and HSV-1 [OR = 1.95 (1.22-3.11); p = 0.005], H. pylori [OR = 1.45 (1.09-1.94); 0.01] and Chlamydia pneumoniae [OR = 1.65 (1.23-2.21); p = 0.001] in women.
conclusionThe metabolic syndrome, which occurs very frequently in the general population, has a significant association with prior infection with Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus and herpes simplex virus type 1. Hypothesis about participation of infection in pathogenesis of metabolic syndrome should be investigated.
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