ArticlePLoS pathogens2006
Endogenous MMTV proviruses induce susceptibility to both viral and bacterial pathogens.
Article in PLoS pathogens, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- A Viral Protein Antagonist for Both AID and APOBEC3.Viruses · 2026Review
- Endogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model.The Journal of clinical investigation · 2024Article
- A Protein Antagonist of Activation-Induced Cytidine Deaminase Encoded by a Complex Mouse Retrovirus.mBio · 2019Article
- Immune responses to endogenous retroelements: taking the bad with the good.Nature reviews. Immunology · 2016Review
- Endogenous mouse mammary tumor viruses (mtv): new roles for an old virus in cancer, infection, and immunity.Frontiers in oncology · 2013Review
- IL-2-independent and TNF-α-dependent expansion of Vβ5+ natural regulatory T cells during retrovirus infection.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Translation of MMTV Gag requires nuclear events involving splicing motifs in addition to the viral Rem protein and RmRE.Retrovirology · 2012Article
- Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Friendly viruses: the special relationship between endogenous retroviruses and their host.Annals of the New York Academy of Sciences · 2009Article
- Mapping of the functional boundaries and secondary structure of the mouse mammary tumor virus Rem-responsive element.The Journal of biological chemistry · 2009Article
- Expression of murine APOBEC3 alleles in different mouse strains and their effect on mouse mammary tumor virus infection.Journal of virology · 2009Article
- BALB/Mtv-null mice responding to strong mouse mammary tumor virus superantigens restrict mammary tumorigenesis.Journal of virology · 2009Article
- MMTV infectious cycle and the contribution of virus-encoded proteins to transformation of mammary tissue.Journal of mammary gland biology and neoplasia · 2008Review
- Human RNA "rumor" viruses: the search for novel human retroviruses in chronic disease.Microbiology and molecular biology reviews : MMBR · 2008Review
- A novel block to mouse mammary tumor virus infection of lymphocytes in B10.BR mice.Journal of virology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Most inbred mice carry germline proviruses of the retrovirus, mouse mammary tumor virus (MMTV) (called Mtvs), which have multiple replication defects. A BALB/c congenic mouse strain lacking all endogenous Mtvs (Mtv-null) was resistant to MMTV oral and intraperitoneal infection and tumorigenesis compared to wild-type BALB/c mice. Infection of Mtv-null mice with an MMTV-related retrovirus, type B leukemogenic virus, also resulted in severely reduced viral loads and failure to induce T-cell lymphomas, indicating that resistance is not dependent on expression of a superantigen (Sag) encoded by exogenous MMTV. Resistance to MMTV in Mtv-null animals was not due to neutralizing antibodies. Further, Mtv-null mice were resistant to rapid mortality induced by intragastric inoculation of the Gram-negative bacterium, Vibrio cholerae, but susceptibility to Salmonella typhimurium was not significantly different from BALB/c mice. Susceptibility to both MMTV and V. cholerae was reconstituted by the presence of any one of three endogenous Mtvs located on different chromosomes and was associated with increased pathogen load. One of these endogenous proviruses is known to encode only Sag. Therefore, Mtv-encoded Sag appears to provide a unique genetic susceptibility to specific viruses and bacteria. Since human endogenous retroviruses also encode Sags, these studies have broad implications for pathogen-induced responses in mice and humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.