ArticleIntervirology2007
Human coronavirus infection among children with acute lower respiratory tract infection in Thailand.
Article in Intervirology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Activities of fungal metabolites sphaeropsidin A and B to fight against canine coronavirus.Veterinary research communications · 2026Article
- Emerging Respiratory Virus Threats from Influenza D and Canine Coronavirus HuPn-2018.Emerging infectious diseases · 2026Review
- Spatiotemporal dynamics and phylogeography of HCoV-NL63 and HCoV-OC43 in Thailand, 2024-2025.PloS one · 2026Article
- Canine coronavirus infection is intensified by 2,3,7,8-tetrachlorodibenzo-p-dioxin.Archives of toxicology · 2025Article
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- Distinct T cell polyfunctional profile in SARS-CoV-2 seronegative children associated with endemic human coronavirus cross-reactivity.iScience · 2024Article
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- Animal alphacoronaviruses found in human patients with acute respiratory illness in different countries.Emerging microbes & infections · 2022Review
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- Behavioral-biological surveillance of emerging infectious diseases among a dynamic cohort in Thailand.BMC infectious diseases · 2022Article
- Biosensors as Nano-Analytical Tools for COVID-19 Detection.Sensors (Basel, Switzerland) · 2021Review
- Point of care detection of COVID-19: Advancement in biosensing and diagnostic methods.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2021Article
- Review a brief history of coronaviruses in Thailand.Journal of virological methods · 2021Review
- Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?Viruses · 2019Review
- Human Coronavirus Infections in Israel: Epidemiology, Clinical Symptoms and Summer Seasonality of HCoV-HKU1.Viruses · 2018Article
- Two-tube multiplex real-time reverse transcription PCR to detect six human coronaviruses.Virologica Sinica · 2016Article
- A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong.Virologica Sinica · 2016Article
- Molecular epidemiology and characterization of human coronavirus in Thailand, 2012-2013.SpringerPlus · 2016Article
- Human coronaviruses: viral and cellular factors involved in neuroinvasiveness and neuropathogenesis.Virus research · 2014Review
- Human coronaviruses: Clinical features and phylogenetic analysis.BioMedicine · 2013Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was performed to further identify the previously uncharacterized human coronavirus 229E (hCoV-229E) and human coronavirus OC43 (hCoV-OC43) in Thailand by using the RT-PCR technique. In addition, we performed this study in order to delineate the prevalence, the potential clinical impacts and evaluation of the genetic characterization of this pathogen in young children who presented with acute lower respiratory tract infections (ALRI).
methodsWe obtained nasopharyngeal secretions (NPs) from 226 children <5 years of age who were either attending the outpatient department or hospitalized with ALRI from March 2002 to July 2003. All clinical, laboratory, RT-PCR, direct sequencing and phylogenetic analysis data were collected and analyzed.
resultsOf the 226 NPs samples from infants and young children presented with ALRI, 8 (3.54%) were positive for hCoV-229E, 2 (0.88%) were positive for hCoV-OC43, and 1 (0.44%) had co-infection. The following clinical presentations were noted: fever (100%), rhinitis (44%), acute bronchiolitis (44%), viral pneumonia (33%), viral pneumonia triggering asthma exacerbation (11%) as well as viral pneumonia causing BPD exacerbation (11%). All positive samples were subjected to direct sequencing. The amino acid sequences had 82-99% similarity to previous sequences stored in the GenBank database.
conclusionThe molecular technique we applied to detect human coronavirus appears justified as a valuable diagnostic approach to elucidate the prevalence, cause and clinical implications of ALRI among infants and young children.
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Registered trials
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