ArticleThe Plant cell2006
The POLARIS peptide of Arabidopsis regulates auxin transport and root growth via effects on ethylene signaling.
Article in The Plant cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
60 citing papers in PubMed, 149 citations in OpenAlex.
- Peptide hormones in shaping root system architecture and environmental adaptation: Current advances and translational perspectives.Plant communications · 2026Review
- The impact of CsPSKs on plant immunity: insights from a genome-wide study of small peptides in Citrus sinensis.Functional & integrative genomics · 2026Article
- POLARIS is a copper-binding peptide that interacts with ETR1 to negatively regulate ethylene signaling in Arabidopsis.Plant communications · 2025Article
- Peptide Hormone-Mediated Regulation of Plant Development and Environmental Adaptability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Review
- MDF Regulates a Network of Auxin-Dependent and Auxin-Independent Pathways of Adventitious Root Regeneration inPlant direct · 2025Article
- lncRNA-Encoded Small Peptide Promotes Viral Infection.Molecular plant pathology · 2025Article
- A predictive model for ethylene-mediated auxin and cytokinin patterning in the Arabidopsis root.Plant communications · 2024Article
- Biological Activity of Artificial Plant Peptides Corresponding to the Translational Products of Small ORFs in Primary miRNAs and Other Long "Non-Coding" RNAs.Plants (Basel, Switzerland) · 2024Review
- The Emerging Role of Non-Coding RNAs (ncRNAs) in Plant Growth, Development, and Stress Response Signaling.Non-coding RNA · 2024Review
- Review
- Integrative Proteomics and Metabolomics Analysis Reveals the Role of Small Signaling Peptide Rapid Alkalinization Factor 34 (RALF34) in Cucumber Roots.International journal of molecular sciences · 2023Article
- From the archives: A rice grain size regulatory module, GWAS of primary plant metabolism, and promoter trapping of polarity markers.The Plant cell · 2022Article
- LncRNA-Encoded Short Peptides Identification Using Feature Subset Recombination and Ensemble Learning.Interdisciplinary sciences, computational life sciences · 2022Article
- Pervasive translation of small open reading frames in plant long non-coding RNAs.Frontiers in plant science · 2022Review
- In Vitro Root Induction from Argan (Plants (Basel, Switzerland) · 2021Article
- The Arabidopsis R-SNARE VAMP714 is essential for polarisation of PIN proteins and auxin responses.The New phytologist · 2021Article
- PIP2, An Auxin Induced Plant Peptide Hormone Regulates Root and Hypocotyl Elongation inFrontiers in plant science · 2021Article
- Long Non-Coding RNAs in Atrial Fibrillation: Pluripotent Stem Cell-Derived Cardiomyocytes as a Model System.International journal of molecular sciences · 2020Review
- Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases.Journal of biomedical science · 2020Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
The rate and plane of cell division and anisotropic cell growth are critical for plant development and are regulated by diverse mechanisms involving several hormone signaling pathways. Little is known about peptide signaling in plant growth; however, Arabidopsis thaliana POLARIS (PLS), encoding a 36-amino acid peptide, is required for correct root growth and vascular development. Mutational analysis implicates a role for the peptide in hormone responses, but the basis of PLS action is obscure. Using the Arabidopsis root as a model to study PLS action in plant development, we discovered a link between PLS, ethylene signaling, auxin homeostasis, and microtubule cytoskeleton dynamics. Mutation of PLS results in an enhanced ethylene-response phenotype, defective auxin transport and homeostasis, and altered microtubule sensitivity to inhibitors. These defects, along with the short-root phenotype, are suppressed by genetic and pharmacological inhibition of ethylene action. PLS expression is repressed by ethylene and induced by auxin. Our results suggest a mechanism whereby PLS negatively regulates ethylene responses to modulate cell division and expansion via downstream effects on microtubule cytoskeleton dynamics and auxin signaling, thereby influencing root growth and lateral root development. This mechanism involves a regulatory loop of auxin-ethylene interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.