Trial reportThe Journal of physiology2007
Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans.
Trial report in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 129 citations in OpenAlex.
- L-Citrulline Supplementation Improves Arterial Blood Flow and Muscle Oxygenation during Handgrip Exercise in Hypertensive Postmenopausal Women.Nutrients · 2024Trial
- Simultaneous Pharmacokinetic Analysis of Nitrate and its Reduced Metabolite, Nitrite, Following Ingestion of Inorganic Nitrate in a Mixed Patient Population.Pharmaceutical research · 2020Trial
- Folic acid ingestion improves skeletal muscle blood flow during graded handgrip and plantar flexion exercise in aged humans.American journal of physiology. Heart and circulatory physiology · 2017Trial
- L-Arginine supplementation does not enhance blood flow and muscle performance in healthy and physically active older women.European journal of nutrition · 2016Trial
- Effects of modest hyperoxia and oral vitamin C on exercise hyperaemia and reactive hyperaemia in healthy young men.European journal of applied physiology · 2015Trial
- Aging is associated with altered vasodilator kinetics in dynamically contracting muscle: role of nitric oxide.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Trial
- Acute ascorbic acid ingestion increases skeletal muscle blood flow and oxygen consumption via local vasodilation during graded handgrip exercise in older adults.American journal of physiology. Heart and circulatory physiology · 2015Trial
- Acute dietary nitrate supplementation enhances compensatory vasodilation during hypoxic exercise in older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Trial
- Roles of nitric oxide and prostaglandins in the hyperemic response to a maximal metabolic stimulus: redundancy prevails.European journal of applied physiology · 2013Trial
- Altered neurovascular control of the resting circulation in human metabolic syndrome.The Journal of physiology · 2012Trial
- Temperature-dependent release of ATP from human erythrocytes: mechanism for the control of local tissue perfusion.Experimental physiology · 2012Trial
- Combined inhibition of nitric oxide and vasodilating prostaglandins abolishes forearm vasodilatation to systemic hypoxia in healthy humans.The Journal of physiology · 2011Trial
- Alpha-adrenergic control of blood flow during exercise: effect of sex and menstrual phase.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Trial
- Nitric oxide, but not vasodilating prostaglandins, contributes to the improvement of exercise hyperemia via ascorbic acid in healthy older adults.American journal of physiology. Heart and circulatory physiology · 2010Trial
- Roles of nitric oxide synthase and cyclooxygenase in leg vasodilation and oxygen consumption during prolonged low-intensity exercise in untrained humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Trial
- Cyclooxygenase-dependent contribution to increased flow mediated dilatation following a week of repeated ischemic preconditioning.European journal of applied physiology · 2026Article
- Blunted brachial blood flow velocity response to acute mental stress in PTSD females.Physiological reports · 2024Article
- Obesity does not alter vascular function and handgrip exercise hemodynamics in middle-aged patients with hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Effect of acute handgrip and aerobic exercise on wasted pressure effort and arterial wave reflections in healthy aging.American journal of physiology. Heart and circulatory physiology · 2023Article
- Association between atherogenic risk-modulating proteins and endothelium-dependent flow-mediated dilation in coronary artery disease patients.European journal of applied physiology · 2023Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In older humans, infusions of endothelial agonists suggest endothelial dysfunction, due in part to less nitric oxide (NO)- and prostaglandin (PG)-mediated vasodilatation, and a shift toward PG-mediated vasoconstriction. Ageing can also be associated with lower exercise blood flow (exercise hyperaemia), but the vascular mechanisms mediating this remain unknown. Notably, in young adults, inhibition of NO and PGs during exercise decreases exercise hyperaemia by approximately 20 and approximately 12%, respectively. We tested our first hypothesis that in older humans inhibition of NO would decrease hyperaemia, but that inhibition of PGs would increase hyperaemia by blocking vasoconstrictor PGs. Fifteen older subjects (65 +/- 3 years) performed dynamic forearm exercise for 20 min (20 contractions min(-1)). Forearm blood flow (FBF) was measured beat-to-beat with Doppler ultrasound, while saline or drugs were infused sequentially via brachial artery catheter in the exercising forearm. After achieving steady-state exercise, L-NAME (25 mg) was infused over 5 min to inhibit NO synthase. After a further 2 min of exercise (saline), ketorolac (6 mg) was infused over 5 min to inhibit PGs, followed by a further 3 min of exercise with saline. Drug order was reversed in seven subjects. L-NAME reduced steady-state exercise hyperaemia by 12 +/- 3% in older subjects (P<0.01), whereas ketorolac had no net effect on blood flow (3 +/- 6%, P>0.4). The effects of l-NAME and ketorolac were independent of drug order. By comparing these results with our previous results in young adults, we tested our second hypothesis that in older humans inhibition of NO or PGs would have less impact on exercise hyperaemia due to less vasodilatation from these signals. Our results suggest that, compared with young adults, in older humans the relative contribution of NO to exercise hyperaemia is reduced approximately 45% (22 +/- 4 versus 12 +/- 3%), but the role of PG in mediating vasodilatation is lost in ageing human skeletal muscle. Lower exercise hyperaemia in older humans may be mediated in part by less NO- and PG-mediated vasodilatation during exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.