Evidence map›Paper›PMID 17137733›Full record

ArticleGene2007

Improved repeat identification and masking in Dipterans.

Christopher D Smith, Robert C Edgar, Mark D Yandell, Douglas R Smith, Susan E Celniker, Eugene W Myers, Gary H Karpen

Abstract read
In one paragraph

Article in Gene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 92 citations in OpenAlex.

  1. Article
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  9. High-quality genome assembly ofFrontiers in microbiology · 2023
    Article
  10. Article
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  12. Draft Genome Sequence of Oleaginous YeastMicrobiology resource announcements · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Frontiers in plant science · 2019
    Article
  17. GAAP: A Genome Assembly + Annotation Pipeline.BioMed research international · 2019
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Christopher D SmithDepartment of Biology, San Francisco State University, San Francisco, CA, United States. cdsmith@fruitfly.org
Robert C Edgar
Mark D Yandell
Douglas R Smith
Susan E Celniker
Eugene W Myers
Gary H Karpen
Lawrence Berkeley National Laboratory · USJanelia Research Campus · USTiburon Associates (United States) · USUniversity of California, Berkeley · USUniversity of Utah · US

Funding

The Drosophila Heterochromatin Genome ProjectR01HG000747 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KARPEN, GARY H · 1992 to 2008
$9.3M
NHGRI NIH HHS HG000747NHGRI NIH HHS R01 HG000747
6 · The paper itself

Abstract

Repetitive sequences are a major constituent of many eukaryote genomes and play roles in gene regulation, chromosome inheritance, nuclear architecture, and genome stability. The identification of repetitive elements has traditionally relied on in-depth, manual curation and computational determination of close relatives based on DNA identity. However, the rapid divergence of repetitive sequence has made identification of repeats by DNA identity difficult even in closely related species. Hence, the presence of unidentified repeats in genome sequences affects the quality of gene annotations and annotation-dependent analyses (e.g. microarray analyses). We have developed an enhanced repeat identification pipeline using two approaches. First, the de novo repeat finding program PILER-DF was used to identify interspersed repetitive elements in several recently finished Dipteran genomes. Repeats were classified, when possible, according to their similarity to known elements described in Repbase and GenBank, and also screened against annotated genes as one means of eliminating false positives. Second, we used a new program called RepeatRunner, which integrates results from both RepeatMasker nucleotide searches and protein searches using BLASTX. Using RepeatRunner with PILER-DF predictions, we masked repeats in thirteen Dipteran genomes and conclude that combining PILER-DF and RepeatRunner greatly enhances repeat identification in both well-characterized and un-annotated genomes.

Indexed as

AnimalsDipteraDNA Transposable ElementsEuchromatinGenome, InsectHeterochromatinRepetitive Sequences, Nucleic AcidSequence Analysis, DNASoftwareSpecies SpecificityTandem Repeat SequencesDNA Transposable ElementsEuchromatinHeterochromatin

Identifiers

PMID17137733
PMCPMC1945102
OpenAlexW2126452926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.