ReviewPhysiology & behavior2007
Modulation of food reward by adiposity signals.
Review in Physiology & behavior, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 152 citations in OpenAlex.
- Gambling on an empty stomach: Hunger modulates preferences for learned but not described risks.Brain and behavior · 2023Trial
- Regional brain response to visual food cues is a marker of satiety that predicts food choice.The American journal of clinical nutrition · 2012Trial
- Acquired hypothalamic obesity: A clinical overview and update.Diabetes, obesity & metabolism · 2024Article
- CNS sites controlling the gastric pyloric sphincter: Neuroanatomical and functional study in the rat.The Journal of comparative neurology · 2023Article
- Obese-associated gut microbes and derived phenolic metabolite as mediators of excessive motivation for food reward.Microbiome · 2023Article
- Effects of estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet.GeroScience · 2022Article
- Hunger improves reinforcement-driven but not planned action.Cognitive, affective & behavioral neuroscience · 2021Article
- Intranasal Insulin: a Treatment Strategy for Addiction.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Central GLP-1 receptors: Novel molecular targets for cocaine use disorder.Physiology & behavior · 2019Review
- Modulation of Feeding and Associated Behaviors by Lateral Hypothalamic Circuits.Endocrinology · 2018Review
- Insulin dependent and independent normalization of blood glucose levels reduces the enhanced rewarding effects of nicotine in a rodent model of diabetes.Behavioural brain research · 2018Article
- Intragastric nutrient infusion reduces motivation for food in male and female rats.American journal of physiology. Endocrinology and metabolism · 2018Article
- Pharmacological interventions for obesity: current and future targets.Current addiction reports · 2018Article
- Review
- To Do or Not to Do: Dopamine, Affordability and the Economics of Opportunity.Frontiers in integrative neuroscience · 2018Article
- Associations Between Environmental Resources and the "Wanting" and "Liking" of Male Song in Female Songbirds.Integrative and comparative biology · 2017Review
- Changes in gene expression and sensitivity of cocaine reward produced by a continuous fat diet.Psychopharmacology · 2017Article
- Central Nervous Insulin Administration before Nocturnal Sleep Decreases Breakfast Intake in Healthy Young and Elderly Subjects.Frontiers in neuroscience · 2017Article
- Reciprocal Inhibitory Interactions Between the Reward-Related Effects of Leptin and Cocaine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Insulin resistance in brain alters dopamine turnover and causes behavioral disorders.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Extensive historical evidence from the drug abuse literature has provided support for the concept that there is functional communication between central nervous system (CNS) circuitries which subserve reward/motivation, and the regulation of energy homeostasis. This concept is substantiated by recent studies that map anatomical pathways, or which demonstrate that hormones and neurotransmitters associated with energy homeostasis regulation can directly modulate reward and motivation behaviors. Studies from our laboratory have focused specifically on the candidate adiposity hormones, insulin and leptin, and show that these hormones can decrease performance in behavioral paradigms that assess the rewarding or motivating properties of food. Additionally we and others have provided evidence that the ventral tegmental area may be one direct target for these effects, and we are currently exploring other potential anatomical targets. Finally, we are beginning to explore the interaction between adiposity signals, chronic maintenance diet of rats, and different types of food rewards to more closely simulate the current food environments of Westernized societies including the U.S. We propose that future studies of food reward should include a more complex environment in the experimental design that takes into account abundance and variety of rewarding foods, psychological stressors, and choices of reward modalities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.