ArticleBMC cancer2006
FGFR1 and WT1 are markers of human prostate cancer progression.
Article in BMC cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Active specific immunotherapy targeting the Wilms' tumor protein 1 (WT1) for patients with hematological malignancies and solid tumors: lessons from early clinical trials.The oncologist · 2012Pooled it
- Decoding the germline genetic architecture of prostate cancer at a single cell resolution.PLoS genetics · 2025Article
- Autocrine Fibroblast Growth Factor Receptor 1 Signaling Activates Lactate Dehydrogenase A-Aerobic Glycolysis for Advanced Human Prostate Tumor Growth.Prostate cancer · 2025Article
- Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer.Cell reports · 2021Article
- The tumor suppressor miR-642a-5p targets Wilms Tumor 1 gene and cell-cycle progression in prostate cancer.Scientific reports · 2021Article
- Wilms' Tumor 1 (WT1): The Vaccine for Cancer.Journal of immunotherapy and precision oncology · 2020Review
- Combined analysis and validation for DNA methylation and gene expression profiles associated with prostate cancer.Cancer cell international · 2019Article
- Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer.Cancer research · 2018Article
- Article
- Overexpression of FGF9 in prostate epithelial cells augments reactive stroma formation and promotes prostate cancer progression.International journal of biological sciences · 2015Article
- Prognosis significance of HER2 status and TACC1 expression in patients with gastric carcinoma.Medical oncology (Northwood, London, England) · 2014Article
- Cellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressor.Biochimica et biophysica acta · 2014Review
- FGFR1 is essential for prostate cancer progression and metastasis.Cancer research · 2013Article
- The Wilms' tumor gene (WT1) regulates E-cadherin expression and migration of prostate cancer cells.Molecular cancer · 2013Article
- Article
- Upregulated FGFR1 expression is associated with the transition of hormone-naive to castrate-resistant prostate cancer.British journal of cancer · 2011Article
- LNCaP Atlas: gene expression associated with in vivo progression to castration-recurrent prostate cancer.BMC medical genomics · 2010Article
- Analysis of gene expression in prostate cancer epithelial and interstitial stromal cells using laser capture microdissection.BMC cancer · 2010Article
- A structure-guided approach to creating covalent FGFR inhibitors.Chemistry & biology · 2010Article
- The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.BMC molecular biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAndrogen-independent prostate adenocarcinomas are responsible for about 6% of overall cancer deaths in men.
methodsWe used DNA microarrays to identify genes related to the transition between androgen-dependent and androgen-independent stages in the LuCaP 23.1 xenograft model of prostate adenocarcinoma. The expression of the proteins encoded by these genes was then assessed by immunohistochemistry on tissue microarrays (TMA) including human prostate carcinoma samples issued from 85 patients who had undergone radical prostatectomy.
resultsFGFR1, TACC1 and WT1 gene expression levels were associated with the androgen-independent stage in xenografts and human prostate carcinoma samples. MART1 protein expression was correlated with pT2 tumor stages.
conclusionOur results suggest that each of these four genes may play a role, or at least reflect a stage of prostate carcinoma growth/development/progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.