ArticleBMC musculoskeletal disorders2006
Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1.
Article in BMC musculoskeletal disorders, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01586377 (Near-infrared Spectroscopic Measurement of Tissue Oxygen Saturation and the Vascular Occlusion Test in Complex Regional Pain Syndrome), which is not on this map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Near-infrared Spectroscopic Measurement of Tissue Oxygen Saturation and the Vascular Occlusion Test in Complex Regional Pain Syndrome
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- Skin biomarkers associated with complex regional pain syndrome (CRPS) Type I: a systematic review.Rheumatology international · 2022Pooled it
- Inflammation in complex regional pain syndrome: a systematic review and meta-analysis.Neurology · 2013Pooled it
- Efficacy and safety of ketamine in patients with complex regional pain syndrome: a systematic review.CNS drugs · 2012Pooled it
- Inhibition of Janus kinase/signal transducer and activator of transcription reduces nociceptive sensitization in a murine model of complex regional pain syndrome.Pain reports · 2026Article
- Thoracic sympathetic block with botulinum toxin A for complex regional pain syndrome: a retrospective case series.Interventional pain medicine · 2026Article
- Efficacy of Immunotherapy for Complex Regional Pain Syndrome: A Narrative Review.Current pain and headache reports · 2025Review
- Article
- Transient immune activation without loss of intraepidermal innervation and associated Schwann cells in patients with complex regional pain syndrome.Journal of neuroinflammation · 2024Article
- Mechanisms of complex regional pain syndrome.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Different Types of Pain in Complex Regional Pain Syndrome Require a Personalized Treatment Strategy.Journal of pain research · 2023Review
- From a Symptom-Based to a Mechanism-Based Pharmacotherapeutic Treatment in Complex Regional Pain Syndrome.Drugs · 2022Review
- [Complex regional pain syndrome-An update].Schmerz (Berlin, Germany) · 2022Article
- Determinants of complex regional pain syndrome type I in patients with scaphoid waist fracture- a multicenter prospective observational study.BMC musculoskeletal disorders · 2022Observational
- [Complex regional pain syndrome-An update].Der Nervenarzt · 2021Article
- Complex Regional Pain Syndrome Type I Following Non-Orthopedic Surgery: Case Report and Narrative Review.Diagnostics (Basel, Switzerland) · 2021Article
- Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States.Frontiers in immunology · 2021Review
- Article
- Molecular Aspects of Regional Pain Syndrome.Pain research & management · 2020Review
- Complex regional pain syndrome: a focus on the autonomic nervous system.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Review
- Perfusion index as a tool to evaluate the efficacy of stellate ganglion block for complex regional pain syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn complex regional pain syndrome type 1 (CRPS1) pro-inflammatory mediators and vascular changes play an important role in the sustained development and outcome of the disease. The aim of this study was to determine the involvement of vasoactive substances endothelin-1 (ET-1) and nitric oxide (NO) during early chronic CRPS1.
methodsIncluded were 29 patients with CRPS 1 who were diagnosed during the acute stage of their disease and observed during follow-up visits. Disease activity and impairment were determined and artificial suction blisters were made on the CRPS1 and the contralateral extremities for measurements of IL-6, TNF-alpha, ET-1 and nitrate/nitrite (NOx).
resultsThe levels of IL-6, TNF-alpha and ET-1 in blister fluid in the CRPS1 extremity versus the contralateral extremity were significantly increased and correlated with each other, whereas NOx levels were decreased.
conclusionThe NOx/ET-1 ratio appears to be disturbed in the intermediate stage of CRPS, resulting in vasoconstriction and consequently in a diminished tissue blood distribution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.