ArticleProceedings of the National Academy of Sciences of the United States of America1991
Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 148 citations in OpenAlex.
- Article
- Molecular characterization of direct interactions between MPP1 and flotillins.Scientific reports · 2021Article
- Not Just Another Scaffolding Protein Family: The Multifaceted MPPs.Molecules (Basel, Switzerland) · 2020Review
- Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling.Cellular signalling · 2020Article
- The Schistosome Esophagus Is a 'Hotspot' for Microexon and Lysosomal Hydrolase Gene Expression: Implications for Blood Processing.PLoS neglected tropical diseases · 2015Article
- Cholesterol Interaction with the MAGUK Protein Family Member, MPP1, via CRAC and CRAC-Like Motifs: An In Silico Docking Analysis.PloS one · 2015Article
- Restricted localization of ponli, a novel zebrafish MAGUK-family protein, to the inner segment interface areas between green, red, and blue cones.Investigative ophthalmology & visual science · 2010Article
- In vivo pharmaco-proteomic analysis of hydroxyurea induced changes in the sickle red blood cell membrane proteome.Journal of proteomics · 2010Article
- Erythrocyte scaffolding protein p55/MPP1 functions as an essential regulator of neutrophil polarity.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Identification of erythrocyte p55/MPP1 as a binding partner of NF2 tumor suppressor protein/Merlin.Experimental biology and medicine (Maywood, N.J.) · 2009Article
- Alternatively spliced exon 5 of the FERM domain of protein 4.1R encodes a novel binding site for erythrocyte p55 and is critical for membrane targeting in epithelial cells.Biochimica et biophysica acta · 2009Article
- Random mutagenesis of PDZ(Omi) domain and selection of mutants that specifically bind the Myc proto-oncogene and induce apoptosis.Oncogene · 2003Article
- Proteomic and functional evidence for a P2X7 receptor signalling complex.The EMBO journal · 2001Article
- Finding the right RNA: identification of cellular mRNA substrates for RNA-binding proteins.RNA (New York, N.Y.) · 1999Article
- Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells.The Journal of cell biology · 1998Article
- ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin.The Journal of cell biology · 1998Article
- Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis: a new X linked contiguous gene deletion syndrome?Journal of medical genetics · 1998Article
- ELL2, a new member of an ELL family of RNA polymerase II elongation factors.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules.The Journal of cell biology · 1997Article
- Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain.The Journal of cell biology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The complete amino acid sequence of a 55-kDa erythrocyte membrane protein was deduced from cDNA clones isolated from a human reticulocyte library. This protein, p55, is copurified during the isolation of dematin, an actin-bundling protein of the erythrocyte membrane cytoskeleton. Fractions enriched in p55 also contain protein kinase activity that completely abolishes the actin-bundling property of purified dematin in vitro. The predicted amino acid sequence of p55 does not contain any consensus sequence corresponding to the catalytic domains of protein kinases but does contain a conserved sequence found in the noncatalytic domains of oncogene-encoded tyrosine kinases. This conserved src homology 3 (SH-3) motif appears to suppress the tyrosine kinase activity of various oncoproteins and has also been found in several plasma membrane associated proteins involved in signal transduction. Northern blot analysis indicated that p55 mRNA was constitutively expressed during erythropoiesis and underwent 2-fold amplification after induction of K562 erythroleukemia cells toward the erythropoietic lineage. The abundant expression of p55 mRNA, along with protein 4.1 mRNA, was evident in terminally differentiated human reticulocytes. Although p55 has many features consistent with known peripheral membrane proteins, its tight association with the plasma membrane is reminiscent of an integral membrane protein. This fact may be partly explained by the observation that p55 is the most extensively palmitoylated protein of the erythrocyte membrane.
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