Evidence map›Paper›PMID 17136613›Full record

ReviewJournal of mammary gland biology and neoplasia2006

Secretion and fluid transport mechanisms in the mammary gland: comparisons with the exocrine pancreas and the salivary gland.

James L McManaman, Mary E Reyland, Edwin C Thrower

Abstract readComparative StudyReview
PubMed Publisher
In one paragraph

Review in Journal of mammary gland biology and neoplasia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Aquaporins in Glandular Secretion.Advances in experimental medicine and biology · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Osteoclast-like giant cell undifferentiated carcinoma of the pancreas: a case report.International journal of clinical and experimental pathology · 2021
    Article
  10. Article
  11. Article
  12. Aquaporin-5: from structure to function and dysfunction in cancer.Cellular and molecular life sciences : CMLS · 2016
    Review
  13. Article
  14. Article
  15. Lipid transport in the lactating mammary gland.Journal of mammary gland biology and neoplasia · 2014
    Review
  16. Cholesterol transport and regulation in the mammary gland.Journal of mammary gland biology and neoplasia · 2014
    Review
  17. Review
  18. Review
  19. Milk secretion: The role of SNARE proteins.Journal of mammary gland biology and neoplasia · 2014
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

James L McManamanDepartment of Obstetrics and Gynecology, University of Colorado Health Sciences Center at Fitzsimons, Mail Stop 8309, P.O. Box 6511, Aurora, CO 80045, USA. jim.mcmanaman@uchsc.edu
Mary E Reyland
Edwin C Thrower
University of Colorado Anschutz Medical Campus · USYale University · US

Funding

The functional role of microRNAs in the normal mammary glandP01HD038129 · NICHD · UNIVERSITY OF COLORADO DENVER · PI ANDERSON, STEVEN M · 2000 to 2015
$15.2M
Regulation of Salivary Cell Apoptosis by Protein Kinase CR01DE015648 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI REYLAND, MARY ELAINE · 2004 to 2019
$5.6M
MECHANISMS OF MILK LIPID SECRETIONR01HD045965 · NICHD · UNIVERSITY OF COLORADO DENVER · PI MCMANAMAN, JAMES LEWIS · 2004 to 2013
$2.8M
Pancreatic zymogen activation in a reconstituted systemR21DK069702 · NIDDK · YALE UNIVERSITY · PI THROWER, EDWIN C · 2005 to 2006
$258k
NICHD NIH HHS P01 HD038129NICHD NIH HHS R01 HD045965NIDCR NIH HHS R01 DE015648NIDDK NIH HHS R21 DK69702
6 · The paper itself

Abstract

Milk is a complex fluid composed of proteins, sugars, lipids and minerals, in addition to a wide variety of bioactive molecules including vitamins, trace elements and growth factors. The composition of these components reflects the integrated activities of distinct synthetic, secretion and transport processes found in mammary epithelial cells, and mirrors the differing nutritional and developmental requirements of mammalian neonates. Five general pathways have been described for secretion of milk components. With the exception of lipids, which are secreted a unique pathway, milk components are thought to be secreted by adaptations of pathways found in other secretory organs. However little is known about the molecular and cellular mechanisms that constitute these pathways or the physiological mechanisms by which they are regulated. Comparisons of current secretion and transport models in the mammary gland, exocrine pancreas and salivary gland indicate that significant differences exist between the mammary gland and other exocrine organs in how proteins and lipids are packaged and secreted, and how fluid is transported.

Indexed as

LactationElectrolytesFemaleHumansLipid MetabolismMammary Glands, HumanPancreas, ExocrineSalivary GlandsElectrolytes

Identifiers

PMID17136613
OpenAlexW2054642279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.