ArticleObesity (Silver Spring, Md.)2006
True fractional calcium absorption is decreased after Roux-en-Y gastric bypass surgery.
Article in Obesity (Silver Spring, Md.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 72 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nutritional Regulation of Bone - Aim 2
Another Revisional Strategy to Address Severe Late Complications After Previous Biliopancreatic Diversion for Obesity: Major Revision From Standard Biliopancreatic Diversion to Proximal Roux-en-Y Gastric Bypass
Who cites it
72 citing papers in PubMed, 3 syntheses or guidelines pooled it, 167 citations in OpenAlex.
- Systematic review of drug bioavailability following gastrointestinal surgery.European journal of clinical pharmacology · 2018Pooled it
- Changes in Bone Metabolism in Morbidly Obese Patients After Bariatric Surgery: A Meta-Analysis.Obesity surgery · 2016Pooled it
- Vitamin D and the bariatric surgical patient: a review.Obesity surgery · 2008Pooled it
- Prebiotic to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial.The Journal of clinical endocrinology and metabolism · 2022Trial
- Effects of Gastric Bypass and Gastric Banding on Bone Remodeling in Obese Patients With Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2016Trial
- Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Trial
- Two-year changes in bone density after Roux-en-Y gastric bypass surgery.The Journal of clinical endocrinology and metabolism · 2015Trial
- Bone mass decreases in morbidly obese women after long limb-biliopancreatic diversion and marked weight loss without secondary hyperparathyroidism. A physiological adaptation to weight loss?Obesity surgery · 2009Trial
- Comparison of the absorption of calcium carbonate and calcium citrate after Roux-en-Y gastric bypass.Obesity surgery · 2009Trial
- The decline in hip bone density after gastric bypass surgery is associated with extent of weight loss.The Journal of clinical endocrinology and metabolism · 2008Trial
- Why Do We Lose Bone During Weight Loss: Can It Be Prevented?Current osteoporosis reports · 2026Review
- Review
- Dynamic Changes in Adiponectin and Resistin Drive Remission of Cardiometabolic Risk Biomarkers in Individuals with Obesity Following Bariatric Surgery.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Long-term trajectories of bone metabolism parameters and bone mineral density (BMD) in obese patients treated with metabolic surgery: a real-world, retrospective study.Journal of endocrinological investigation · 2023Article
- Pre-Operative Bariatric Surgery Imparts An Increased Risk of Infection, Re-Admission and Operative Intervention Following Elective Instrumented Lumbar Fusion.Global spine journal · 2023Article
- Intestinal Calcium Absorption Decreases After Laparoscopic Sleeve Gastrectomy Despite Optimization of Vitamin D Status.The Journal of clinical endocrinology and metabolism · 2023Observational
- Association of Bariatric Surgery With Cancer Incidence in Patients With Obesity and Diabetes: Long-term Results From the Swedish Obese Subjects Study.Diabetes care · 2022Article
- Zoledronic acid for prevention of bone loss in patients receiving bariatric surgery.Bone reports · 2021Article
- Nutritional Assessment and Preparation for Adult Bariatric Surgery Candidates: Clinical Practice.Advances in nutrition (Bethesda, Md.) · 2021Review
- Long-term Bone Loss and Deterioration of Microarchitecture After Gastric Bypass in African American and Latina Women.The Journal of clinical endocrinology and metabolism · 2021Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveRoux-en-Y gastric bypass (RYGB) is considered to be the gold standard alternative treatment for severe obesity. Weight loss after RYGB results primarily from decreased food intake. Inadequate calcium (Ca) intake and metabolic bone disease can occur after gastric bypass. To our knowledge, whether malabsorption of Ca contributes to an altered Ca metabolism in the RYGB patient has not been addressed previously. RESEARCH METHODS AND PROCEDURES: We recruited 25 extremely obese women in order to study true fractional Ca absorption (TFCA) before and 6 months after RYGB surgery, using a dual stable isotope method ((42)Ca and (43)Ca) and test load of Ca (200 mg). Hormones regulating Ca absorption and markers of bone turnover were also measured.
resultsIn 21 women (BMI 52.7 +/- 8.3 kg/m(2), age 43.9 +/- 10.4 years) who successfully completed the study, TFCA decreased from 0.36 +/- 0.08 to 0.24 +/- 0.09 (p < 0.001) after RYGB. Bone turnover markers increased significantly (p < 0.01). TFCA correlated with estradiol levels (r = 0.512, p < 0.02) and tended to correlate with 1,25 (OH)(2)D (r = 0.427, p < 0.06) at final measurement. Stepwise linear regression indicated that estradiol explained 62% of the variance for TFCA at 6 months post-surgery (p < 0.01). DISCUSSION: TFCA decreases (0.12 +/- 0.08) after RYGB surgery but remains within normal range. Although only some patients were estimated to have low Ca absorption after surgery, all of the patients showed a dramatic increase in markers of bone resorption. The alteration in Ca metabolism after RYGB-induced weight loss appears to be regulated primarily by estradiol levels and might ultimately affect bone mass.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.