ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Operant conditioning of H-reflex can correct a locomotor abnormality after spinal cord injury in rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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Who cites it
62 citing papers in PubMed, 117 citations in OpenAlex.
- Change in Reciprocal Inhibition of the Forearm with Motor Imagery among Patients with Chronic Stroke.Neural plasticity · 2018Trial
- Spinal associative stimulation: a non-invasive stimulation paradigm to modulate spinal excitability.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2011Trial
- Neurorehabilitation in the 21st Century: New Science, New Strategies, New Expectations.Neurorehabilitation and neural repair · 2026Review
- Methodological optimization for eliciting robust median nerve somatosensory evoked potentials for realtime single trial applications.Journal of neural engineering · 2026Article
- Current status and future prospects of brain-computer interfaces in the field of neurological disease rehabilitation.Frontiers in rehabilitation sciences · 2026Review
- Electrophysiological evidence of Hebbian plasticity in awake adult rats.Journal of neurophysiology · 2025Article
- Frequency dependence of cortical somatosensory evoked response to peripheral nerve stimulation with controlled afferent excitation.Journal of neural engineering · 2025Article
- Motor learning changes the axon initial segment of the spinal motoneuron.The Journal of physiology · 2024Article
- Contemporary Views of the Extraction, Health Benefits, and Industrial Integration of Rice Bran Oil: A Prominent Ingredient for Holistic Human Health.Foods (Basel, Switzerland) · 2024Review
- Dynamic spinal reflex adaptation during locomotor adaptation.Journal of neurophysiology · 2023Article
- Enhancing neurorehabilitation by targeting beneficial plasticity.Frontiers in rehabilitation sciences · 2023Review
- The Evoked Potential Operant Conditioning System (EPOCS): A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders.Journal of visualized experiments : JoVE · 2022Article
- Heksor: the central nervous system substrate of an adaptive behaviour.The Journal of physiology · 2022Article
- Targeting neuroplasticity to improve motor recovery after stroke: an artificial neural network model.Brain communications · 2022Article
- How Does the Central Nervous System for Posture and Locomotion Cope With Damage-Induced Neural Asymmetry?Frontiers in systems neuroscience · 2022Review
- Control of Mammalian Locomotion by Somatosensory Feedback.Comprehensive Physiology · 2021Article
- Corticospinal Motor Circuit Plasticity After Spinal Cord Injury: Harnessing Neuroplasticity to Improve Functional Outcomes.Molecular neurobiology · 2021Review
- H-reflex conditioning during locomotion in people with spinal cord injury.The Journal of physiology · 2021Article
- Targeting Sensory and Motor Integration for Recovery of Movement After CNS Injury.Frontiers in neuroscience · 2021Review
- A model for the transfer of control from the brain to the spinal cord through synaptic learning.Journal of computational neuroscience · 2020Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
This study asked whether operant conditioning of the H-reflex can modify locomotion in spinal cord-injured rats. Midthoracic transection of the right lateral column of the spinal cord produced a persistent asymmetry in the muscle activity underlying treadmill locomotion. The rats were then either exposed or not exposed to an H-reflex up-conditioning protocol that greatly increased right soleus motoneuron response to primary afferent input, and locomotion was reevaluated. H-reflex up-conditioning increased the right soleus burst and corrected the locomotor asymmetry. In contrast, the locomotor asymmetry persisted in the control rats. These results suggest that appropriately selected reflex conditioning protocols might improve function in people with partial spinal cord injuries. Such protocols might be especially useful when significant regeneration becomes possible and precise methods for reeducating the regenerated spinal cord neurons and synapses are needed for restoring effective function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.