ArticleNucleic acids research2007
CellCircuits: a database of protein network models.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Mechanism-Centric Approaches for Biomarker Detection and Precision Therapeutics in Cancer.Frontiers in genetics · 2021Review
- Systems biology approach to studying proliferation-dependent prognostic subnetworks in breast cancer.Scientific reports · 2015Article
- Identification of diagnostic subnetwork markers for cancer in human protein-protein interaction network.BMC bioinformatics · 2010Article
- An integrated systems analysis implicates EGR1 downregulation in simian immunodeficiency virus encephalitis-induced neural dysfunction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Update of KDBI: Kinetic Data of Bio-molecular Interaction database.Nucleic acids research · 2009Article
- A novel Cas family member, HEPL, regulates FAK and cell spreading.Molecular biology of the cell · 2008Article
- Selective Raf inhibition in cancer therapy.Expert opinion on therapeutic targets · 2007Review
- Network-based classification of breast cancer metastasis.Molecular systems biology · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CellCircuits (http://www.cellcircuits.org) is an open-access database of molecular network models, designed to bridge the gap between databases of individual pairwise molecular interactions and databases of validated pathways. CellCircuits captures the output from an increasing number of approaches that screen molecular interaction networks to identify functional subnetworks, based on their correspondence with expression or phenotypic data, their internal structure or their conservation across species. This initial release catalogs 2019 computationally derived models drawn from 11 journal articles and spanning five organisms (yeast, worm, fly, Plasmodium falciparum and human). Models are available either as images or in machine-readable formats and can be queried by the names of proteins they contain or by their enriched biological functions. We envision CellCircuits as a clearinghouse in which theorists may distribute or revise models in need of validation and experimentalists may search for models or specific hypotheses relevant to their interests. We demonstrate how such a repository of network models is a novel systems biology resource by performing several meta-analyses not currently possible with existing databases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.