ArticleComparative biochemistry and physiology. Part B, Biochemistry & molecular biology2007
Arthropod D2 receptors positively couple with cAMP through the Gi/o protein family.
Article in Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- The Role and Mechanisms of G protein-coupled receptors in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Analysis of adaptive molecular mechanisms in response to low salinity in antennal gland of mud crab,Heliyon · 2024Article
- MicroRNA ame-let-7 targets Amdop2 to increase sucrose sensitivity in honey bees (Apis mellifera).Frontiers in zoology · 2023Article
- The dynamic range of voltage-dependent gap junction signaling is maintained byJournal of neurophysiology · 2022Article
- Identification of putative amine receptor complement in the eyestalk of the crayfish, Procambarus clarkii.Invertebrate neuroscience : IN · 2019Article
- Cloning and functional characterization of the DA2 receptor gene in Chinese mitten crab (Eriocheir sinensis).PloS one · 2018Article
- Monoaminergic tone supports conductance correlations and stabilizes activity features in pattern generating neurons of the lobster, Panulirus interruptus.Frontiers in neural circuits · 2015Article
- Article
- D1-like dopamine receptors downregulate Na+-K+-ATPase activity and increase cAMP production in the posterior gills of the blue crab Callinectes sapidus.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Characterization of an invertebrate-type dopamine receptor of the American cockroach, Periplaneta americana.International journal of molecular sciences · 2014Article
- Dopaminergic tone regulates transient potassium current maximal conductance through a translational mechanism requiring D1Rs, cAMP/PKA, Erk and mTOR.BMC neuroscience · 2013Article
- Review
- Tonic dopamine induces persistent changes in the transient potassium current through translational regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Dopamine-induced oscillations of the pyloric pacemaker neuron rely on release of calcium from intracellular stores.Journal of neurophysiology · 2011Article
- Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis.BMC genomics · 2011Article
- Article
- Cell specific dopamine modulation of the transient potassium current in the pyloric network by the canonical D1 receptor signal transduction cascade.Journal of neurophysiology · 2010Article
- Dopamine modulates Ih in a motor axon.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- D(2) receptors receive paracrine neurotransmission and are consistently targeted to a subset of synaptic structures in an identified neuron of the crustacean stomatogastric nervous system.The Journal of comparative neurology · 2010Article
- Crustacean dopamine receptors: localization and G protein coupling in the stomatogastric ganglion.Journal of neurochemistry · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The pyloric network is an important model system for understanding neuromodulation of rhythmic motor behaviors like breathing or walking. Dopamine (DA) differentially modulates neurons within the pyloric network. However, while the electrophysiological actions of DA have been well characterized, nothing is known about the signaling events that mediate its effects. We have begun a molecular characterization of DA receptors (DARs) in this invertebrate system. Here, we describe the cloning and characterization of the lobster D(2) receptor, D(2 alpha Pan). We found that when expressed in HEK cells, the D(2 alpha Pan) receptor is activated by DA, but not other monoamines endogenous to the lobster nervous system. This receptor positively couples with cAMP through multiple Gi/o proteins via two discrete pathways: 1) a G alpha mediated inhibition of adenylyl cyclase (AC), leading to a decrease in cAMP and 2) a G beta gamma-mediated activation of phospholipase C beta (PLC beta), leading to an increase in cAMP. Alternate splicing alters the potency and efficacy of the receptor, but does not affect monoamine specificity. Finally, we show that arthropod D(2) receptor coupling with cAMP varies with the cellular milieu.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.