ReviewTrends in neurosciences2007
Nur77 and retinoid X receptors: crucial factors in dopamine-related neuroadaptation.
Review in Trends in neurosciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 98 citations in OpenAlex.
- Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers.eLife · 2026Article
- Epigenetic Signatures of Social Defeat Stress Varying Duration.International journal of molecular sciences · 2025Article
- Targeting the nuclear orphan receptor NR4A1: a key target in lung cancer progression and therapeutic resistance.Frontiers in oncology · 2025Review
- Neuronal SLC39A8 deficiency impairs cerebellar development by altering manganese homeostasis.JCI insight · 2024Article
- Is There a Natural, Non-addictive, and Non-anti-reward, Safe, Gene-based Solution to Treat Reward Deficiency Syndrome? KB220 Variants vs GLP-1 Analogs.Journal of addiction psychiatry · 2024Article
- Dose mediates the protracted effects of adolescent THC exposure on reward and stress reactivity in males relevant to perturbation of the basolateral amygdala transcriptome.Molecular psychiatry · 2023Article
- Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement.Molecular neurobiology · 2022Review
- Therapeutic insights elaborating the potential of retinoids in Alzheimer's disease.Frontiers in pharmacology · 2022Review
- Preventive Vitamin A Supplementation Improves Striatal Function in 6-Hydroxydopamine Hemiparkinsonian Rats.Frontiers in nutrition · 2022Article
- The Role of Vitamins in Neurodegenerative Disease: An Update.Biomedicines · 2021Review
- The nuclear receptor 4A family members: mediators in human disease and autophagy.Cellular & molecular biology letters · 2020Review
- Neuroprotective Effect of Antioxidants in the Brain.International journal of molecular sciences · 2020Review
- Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes.Nature communications · 2020Article
- Omega-3 Fatty Acids as Druggable Therapeutics for Neurodegenerative Disorders.CNS & neurological disorders drug targets · 2019Review
- N-3 (Omega-3) Fatty Acids: Effects on Brain Dopamine Systems and Potential Role in the Etiology and Treatment of Neuropsychiatric Disorders.CNS & neurological disorders drug targets · 2018Review
- The involvement of DARPP-32 in the pathophysiology of schizophrenia.Oncotarget · 2017Review
- Contra-directional Coupling of Nur77 and Nurr1 in Neurodegeneration: A Novel Mechanism for Memantine-Induced Anti-inflammation and Anti-mitochondrial Impairment.Molecular neurobiology · 2016Article
- Nur77 exacerbates PC12 cellular injury in vitro by aggravating mitochondrial impairment and endoplasmic reticulum stress.Scientific reports · 2016Article
- Nuclear receptor 4A (NR4A) family - orphans no more.The Journal of steroid biochemistry and molecular biology · 2016Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Dopaminergic systems in the brain adapt in response to various stimuli from the internal and external world, but the mechanisms underlying this process are incompletely understood. Here, we review recent evidence that certain types of transcription factor of the nuclear receptor family, specifically Nur77 and retinoid X receptors, have important roles in adaptation and homeostatic regulation of dopaminergic systems. These findings call for a reassessment of our fundamental understanding of the molecular and cellular basis of dopamine-mediated transmission. Given that diseases such as Parkinson's disease and schizophrenia are thought to involve adaptation of dopamine signalling, these findings might provide new insight into these pathologies and offer new avenues for drug development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.