ArticleDevelopmental biology2007
Regulation of Xenopus gastrulation by ErbB signaling.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Ash2l, an obligatory component of H3K4 methylation complexes, regulates neural crest development.Developmental biology · 2022Article
- Article
- Identification of new regulators of embryonic patterning and morphogenesis in Xenopus gastrulae by RNA sequencing.Developmental biology · 2017Article
- Bimodal regulation of Dishevelled function by Vangl2 during morphogenesis.Human molecular genetics · 2017Article
- Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development.Development (Cambridge, England) · 2015Article
- Dynamic landscape of tandem 3' UTRs during zebrafish development.Genome research · 2012Article
- Regulation of early xenopus embryogenesis by Smad ubiquitination regulatory factor 2.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- The cytoplasmic tyrosine kinase Arg regulates gastrulation via control of actin organization.Developmental biology · 2012Article
- Regulation of early Xenopus development by the PIAS genes.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- ErbB/EGF signaling and EMT in mammary development and breast cancer.Journal of mammary gland biology and neoplasia · 2010Review
- The role of NRG3 in mammary development.Journal of mammary gland biology and neoplasia · 2008Review
- Lrig3 regulates neural crest formation in Xenopus by modulating Fgf and Wnt signaling pathways.Development (Cambridge, England) · 2008Article
- Mechanism of activation of the Formin protein Daam1.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Xenopus ADAM19 is involved in neural, neural crest and muscle development.Mechanisms of developmentArticle
- PI3K and Erk MAPK mediate ErbB signaling in Xenopus gastrulation.Mechanisms of developmentArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During Xenopus gastrulation, mesendodermal cells are internalized and display different movements. Head mesoderm migrates along the blastocoel roof, while trunk mesoderm undergoes convergent extension (C&E). Different signals are implicated in these processes. Our previous studies reveal that signals through ErbB receptor tyrosine kinases modulate Xenopus gastrulation, but the mechanisms employed are not understood. Here we report that ErbB signals control both C&E and head mesoderm migration. Inhibition of ErbB pathway blocks elongation of dorsal marginal zone explants and activin-treated animal caps without removing mesodermal gene expression. Bipolar cell shape and cell mixing in the dorsal region are impaired. Inhibition of ErbB signaling also interferes with migration of prechordal mesoderm on fibronectin. Cell-cell and cell-matrix interaction and cell spreading are reduced when ErbB signaling is blocked. Using antisense morpholino oligonucleotides, we show that ErbB4 is involved in Xenopus gastrulation morphogenesis, and it partially regulates cell movements through modulation of cell adhesion and membrane protrusions. Our results reveal for the first time that vertebrate ErbB signaling modulates gastrulation movements, thus providing a novel pathway, in addition to non-canonical Wnt and FGF signals, that controls gastrulation. We further demonstrate that regulation of cell adhesive properties and cell morphology may underlie the functions of ErbBs in gastrulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.