ArticleBehavioral and brain functions : BBF2006
Association study of the vesicular monoamine transporter 1 (VMAT1) gene with schizophrenia in a Japanese population.
Article in Behavioral and brain functions : BBF, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Dopaminergic Epistases in Schizophrenia.Brain sciences · 2024Review
- Early Detection and Prevention of Schizophrenic Psychosis-A Review.Brain sciences · 2021Review
- CalPen (Calculator of Penetrance), a web-based tool to estimate penetrance in complex genetic disorders.PloS one · 2020Article
- Positive and balancing selection onEvolution letters · 2018Article
- Association Study of VMAT1 Polymorphisms and Suicide Behavior.Journal of molecular neuroscience : MN · 2018Article
- Assessment of individual differences in the rat nucleus accumbens transcriptome following taste-heroin extended access.Brain research bulletin · 2016Article
- Altered expression of mRNA profiles in blood of early-onset schizophrenia.Scientific reports · 2016Article
- Functional genetic variants in the vesicular monoamine transporter 1 modulate emotion processing.Molecular psychiatry · 2014Article
- VMAT1 deletion causes neuronal loss in the hippocampus and neurocognitive deficits in spatial discrimination.Neuroscience · 2013Article
- Genomics and pharmacogenomics of schizophrenia.CNS neuroscience & therapeutics · 2011Review
- Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia.The American journal of psychiatry · 2011Article
- Possible association between interleukin-1β gene and schizophrenia in a Japanese population.Behavioral and brain functions : BBF · 2011Article
- Vesicular monoamine transporters: structure-function, pharmacology, and medicinal chemistry.Medicinal research reviews · 2011Review
- Monoamine transporters: vulnerable and vital doorkeepers.Progress in molecular biology and translational science · 2011Review
- Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat.Human molecular genetics · 2010Article
- Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer.Molecular psychiatry · 2009Review
- Association between polymorphisms in the vesicle-associated membrane protein-associated protein A (VAPA) gene on chromosome 18p and bipolar disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2008Article
- Dopamine genes and schizophrenia: case closed or evidence pending?Schizophrenia bulletin · 2007Review
- Expression of the Vesicular Monoamine Transporter Gene Solute Carrier Family 18 Member 1 (Cancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVesicular monoamine transporters (VMATs) mediate accumulation of monoamines such as serotonin, dopamine, adrenaline, and noradrenaline from the cytoplasm into storage organelles. The VMAT1 (alternatively solute carrier family 18: SLC18A1) regulates such biogenic amines in neuroendocrine systems. The VMAT1 gene maps to chromosome 8p21.3, a locus with strong evidence of linkage with schizophrenia. A recent study reported that a non-synonymous single nucleotide polymorphism (SNP) of the gene (Pro4Thr) was associated with schizophrenia.
methodsWe attempted to replicate this finding in a Japanese sample of 354 schizophrenics and 365 controls. In addition, we examined 3 other non-synonymous SNPs (Thr98Ser, Thr136Ile, and Val392Leu). Genotyping was performed by the TaqMan allelic discrimination assay.
resultsThere was no significant difference in genotype or allele distribution of the three SNPs of Pro4Thr, Thr136Ile, or Val392Leu between patients and controls. There was, however, a significant difference in genotype and allele distributions for the Thr98Ser polymorphism between the two groups (P = 0.01 for genotype and allele). When sexes were examined separately, significant differences were observed in females (P = 0.006 for genotype, P = 0.003 for allele), but not in males. The Thr98 allele was more common in female patients than in female controls (odds ratio 1.69, 95% CI 1.19-2.40, P = 0.003). Haplotype-based analyses also provided evidence for a significant association in females.
conclusionWe failed to replicate the previously reported association of Pro4Thr of the VMAT1 gene with schizophrenia. However, we obtained evidence for a possible role of the Thr98Ser in giving susceptibility to schizophrenia in women.
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Registered trials
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