ArticleBMC gastroenterology2006
Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor.
Article in BMC gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Plasminogen Activation System and Fibroblasts: Impact on Tissue Remodeling, Disease, and Organ Homeostasis.Inflammation · 2026Review
- Exploring the impact of DEP on pediatric Crohn's disease using machine learning and molecular docking methods.Frontiers in pediatrics · 2026Article
- Human umbilical cord mesenchymal stem cells ameliorate liver fibrosis by inhibiting hepatocyte ferroptosis and macrophage polarization via the miR-455-3p/PLAU axis.Stem cell research & therapy · 2025Article
- Fibrinolysis-Mediated Pathways in Acute Liver Injury.Seminars in thrombosis and hemostasis · 2024Review
- Critical Role of LSEC in Post-Hepatectomy Liver Regeneration and Failure.International journal of molecular sciences · 2021Review
- A cytokine receptor-masked IL2 prodrug selectively activates tumor-infiltrating lymphocytes for potent antitumor therapy.Nature communications · 2021Article
- Fibrinolytic Serine Proteases, Therapeutic Serpins and Inflammation: Fire Dancers and Firestorms.Frontiers in cardiovascular medicine · 2021Review
- Elevated levels of serum urokinase plasminogen activator predict poor prognosis in hepatocellular carcinoma after resection.BMC cancer · 2019Article
- Kinetics of the soluble urokinase plasminogen activator receptor (suPAR) in cirrhosis.PloS one · 2019Article
- Transcriptomic pathway analysis of urokinase receptor silenced breast cancer cells: a microarray study.Oncotarget · 2017Article
- Brahma compensates the role of brahma-related gene 1 in liver regeneration ofInternational journal of clinical and experimental pathology · 2017Article
- Article
- Human urokinase-type plasminogen activator gene-modified bone marrow-derived mesenchymal stem cells attenuate liver fibrosis in rats by down-regulating the Wnt signaling pathway.World journal of gastroenterology · 2016Article
- Silymarin Accelerates Liver Regeneration after Partial Hepatectomy.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation.World journal of gastroenterology · 2014Article
- Article
- Coexpression of Smad7 and UPA attenuates carbon tetrachloride-induced rat liver fibrosis.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Article
- Lack of guanylate cyclase C results in increased mortality in mice following liver injury.BMC gastroenterology · 2010Article
- Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe urokinase-type (uPA) and tissue-type (tPA) plasminogen activators regulate liver matrix remodelling through the conversion of plasminogen (Plg) to the active protease plasmin. Based on the efficient activation of plasminogen when uPA is bound to its receptor (uPAR) and on the role of uPA in plasmin-mediated liver repair, we hypothesized that uPA requires uPAR for efficient liver repair.
methodsTo test this hypothesis, we administered one dose of carbon tetrachloride (CCl4) to mice with single or combined deficiencies of uPA, uPAR and tPA, and examined hepatic morphology, cellular proliferation, fibrin clearance, and hepatic proteolysis 2-14 days later.
resultsAbsence of uPAR alone or the combined absence of uPAR and tPA had no impact on the resolution of centrilobular injury, but the loss of receptor-free uPA significantly impaired the clearance of necrotic hepatocytes up to 14 days after CCl4. In response to the injury, hepatocyte proliferation was normal in mice of all genotypes, except for uPAR-deficient (uPAR degrees) mice, which had a reproducible but mild decrease by 33% at day 2, with an appropriate restoration of liver mass by 7 days similar to experimental controls. Immunostaining and zymographic analysis demonstrated that uPA alone promoted fibrin clearance from centrilobular regions and efficiently activated plasminogen.
conclusionuPA activates plasminogen and promotes liver matrix proteolysis during repair via a process that neither requires its receptor uPAR nor requires a contribution from its functional counterpart tPA.
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Registered trials
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