ArticlePflugers Archiv : European journal of physiology1991
Effects of ATP antagonists on purinoceptor-operated inward currents in rat phaeochromocytoma cells.
Article in Pflugers Archiv : European journal of physiology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- Perilymphatic ATP plays a critical role in modulating cochlear function to protect from loud sound induced hearing loss.EBioMedicine · 2026Article
- Convergent synthesis of the potent P2Y receptor antagonist MG 50-3-1 based on a regioselective Ullmann coupling reaction.Molecules (Basel, Switzerland) · 2012Article
- Activation and regulation of purinergic P2X receptor channels.Pharmacological reviews · 2011Review
- Synthesis of alkyl- and aryl-amino-substituted anthraquinone derivatives by microwave-assisted copper(0)-catalyzed Ullmann coupling reactions.Nature protocols · 2010Article
- Purine receptor antagonist modulates serology and affective behaviors in lupus-prone mice: evidence of autoimmune-induced pain?Brain, behavior, and immunity · 2008Article
- Methyllycaconitine, alpha-bungarotoxin and (+)-tubocurarine block fast ATP-gated currents in rat dorsal root ganglion cells.British journal of pharmacology · 2004Article
- Characterization of specific GTP binding sites in C2C12 mouse skeletal muscle cells.Journal of muscle research and cell motility · 2002Article
- Single channel properties of P2X2 purinoceptors.The Journal of general physiology · 1999Article
- Ca2+-permeable P2X receptor channels in cultured rat retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- P2x-purinoceptors of myenteric neurones from the guinea-pig ileum and their unusual pharmacological properties.British journal of pharmacology · 1996Article
- Functional characterisation of P2 purinoceptors in PC12 cells by measurement of radiolabelled calcium influx.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- P2X4: an ATP-activated ionotropic receptor cloned from rat brain.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- An ATP-activated, ligand-gated ion channel on a cholinergic presynaptic nerve terminal.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- New insights on P2X purinoceptors.Naunyn-Schmiedeberg's archives of pharmacology · 1995Review
- Quinine sensitive changes in cellular Na+ and K+ homeostasis of COS-7 cells caused by a lipophilic phenol red impurity.In vitro cellular & developmental biology. Animal · 1995Article
- Inhibition by suramin and reactive blue 2 of GABA and glutamate receptor channels in rat hippocampal neurons.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- ATP and endogenous agonists inhibit evoked [3H]-noradrenaline release in rat iris via A1 and P2y-like purinoceptors.Naunyn-Schmiedeberg's archives of pharmacology · 1993Article
- Mechanisms underlying facilitation by dopamine of ATP-activated currents in rat pheochromocytoma cells.Pflugers Archiv : European journal of physiology · 1993Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of suramin, reactive blue 2 (RB2) and d-tubocurarine (d-TC) were investigated electrophysiologically to elucidate the mechanisms underlying their antagonism of P2 purinoceptor-mediated responses. All three compounds inhibited an adenosine triphosphate (ATP)-activated inward current in rat phaeochromocytoma PC12 cells in a concentration-dependent manner. The order of potency was RB2 greater than suramin greater than d-TC. The inhibition induced by suramin or RB2 was reversible, whereas that induced by d-TC was not reversed after a 5-min rinse. The inactivation of the ATP-activated current was accelerated by d-TC but not by suramin or RB2. RB2 administered simultaneously with ATP exerted much weaker inhibition compared to that induced by prior administration, suggesting that RB2 is a slowly acting antagonist. This was not observed for suramin or d-TC. Suramin and RB2 caused a parallel shift in the concentration/response curve for the ATP-activated current. With d-TC the maximal response of ATP was decreased but the concentration producing half-maximal response was unchanged. The voltage dependency of the ATP-activated current showed less inward rectification in the presence of d-TC. Suramin or RB2 did not affect the voltage dependency. These results suggest that suramin and RB2 reversibly block binding of ATP to receptors, whereas d-TC blocks ion permeability through the ATP-activated channel.
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