Evidence map›Paper›PMID 17132874›Full record

ReviewStem cell reviews2005

Stem cell plasticity: a rare cell, not a rare event.

Yoon-Young Jang, Saul J Sharkis

Abstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Toward 'SMART' stem cells.Gene therapy · 2008
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yoon-Young JangSidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Saul J Sharkis

Funding

EXPERIMENTAL HEMATOPOIETIC STEM CELL GROWTHR01HL054330 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SHARKIS, SAUL JOSEPH · 1996 to 2006
$3.1M
NHLBI NIH HHS R01HL54330
6 · The paper itself

Abstract

Purification to homogeneity for a rare stem cell (SC) population by both function and phenotype is a prerequisite to determine if SCs can change their fate (plasticity). Since cell fate determination has been suggested by both external environmental cues and intrinsic gene regulation, plasticity should be studied using both influences. Different frequencies of marrow SC plasticity may be attributed to either different isolation technologies or different developmental stage SCs with more or less multipotentiality. Tissue-specific SCs may reside in marrow, or alternatively, primitive marrow SC may respond directly to regenerative signals by migration to injury sites and repairing the damaged tissue. It is important to dissect the relationship between primitive/tissue-specific SCs and regenerative signals.

Indexed as

Cell DifferentiationCell FusionChromosome MappingEpithelial CellsGenetic MarkersGene Transfer TechniquesHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHumansRNA, MessengerStem CellsTissue DonorsGenetic MarkersRNA, Messenger

Identifiers

PMID17132874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.