Evidence map›Paper›PMID 17132773›Full record

ReviewAnnals of the New York Academy of Sciences2006

Cell-based approaches for cardiac repair.

Michael Rubart, Loren J Field

Abstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?Oxidative medicine and cellular longevity · 2019
    Review
  2. Germline Stem Cells in Myocardial Regeneration - A new hope worth a delve.Journal of stem cells & regenerative medicine · 2018
    Article
  3. Review
  4. Article
  5. Article
  6. Application of stem cells in orthopedics.Stem cells international · 2012
    Article
  7. Molecular mechanisms of cardiomyocyte aging.Clinical science (London, England : 1979) · 2011
    Review
  8. Article
  9. The cardiomyocyte lineage is critical for optimization of stem cell therapy in a mouse model of myocardial infarction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael RubartHerman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut Street, RM W376, Indianapolis, IN 46202, USA.
Loren J Field

Funding

Genetic Enhancement of Cardiac Repair with Adult Stem CellsR01HL083126 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI FIELD, LOREN J · 2006 to 2015
$2.9M
Functional assessment of donor-host cell couplingR01HL075165 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI RUBART-VAN DER LOHE, MICHAEL · 2005 to 2009
$2.1M
NHLBI NIH HHS R01 HL075165NHLBI NIH HHS R01 HL083126
6 · The paper itself

Abstract

Many forms of cardiovascular disease are associated with cardiomyocyte loss via necrosis and/or apoptosis. The cumulative loss of contractile cells ultimately results in diminished cardiac function. Numerous approaches have been employed to reduce the rate of cardiomyocyte loss, or alternatively, to repopulate the heart with new cardiomyocytes. Strategies aimed at repopulating the heart include cardiomyocyte cell therapy, myogenic stem cell therapy, and cell cycle activation therapy. All three approaches are based on the assumption that the de novo cardiomyocytes will participate in a functional syncytium with the surviving myocardium. This review will discuss the current status of interventions aimed at repopulating the heart with functional cardiomyocytes.

Indexed as

AnimalsCell CycleCell TransplantationHeart DiseasesHumans

Identifiers

PMID17132773
PMCPMC2600713

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.