ArticleProceedings of the National Academy of Sciences of the United States of America2006
Silencing leaf sorbitol synthesis alters long-distance partitioning and apple fruit quality.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 154 citations in OpenAlex.
- Allelic variation in the thioredoxin TRX-M4 influences carbon partitioning to control soluble sugar content in apple fruit.Plant communications · 2026Article
- Understanding Chilling Injury and Sugar Metabolism-Related Genes and Metabolites in 'Red Haven' Peaches.Plants (Basel, Switzerland) · 2025Article
- Comparative transcriptome analyses and CRISPR/Cas9-mediated functional study ofFrontiers in microbiology · 2025Article
- A linker histone acts as a transcription factor to orchestrate malic acid accumulation in apple in response to sorbitol.The Plant cell · 2024Article
- Sorbitol signaling: Linker histone MdH1.1 modulates malic acid buildup in apple.The Plant cell · 2024Article
- Evolutionary dynamics and functional characterization of proximal duplicated sorbitol-6-phosphate dehydrogenase genes in Rosaceae.Frontiers in plant science · 2024Article
- Transcriptome and Metabolome Analyses Reveal Sugar and Acid Accumulation during Apricot Fruit Development.International journal of molecular sciences · 2023Article
- Physicochemical Attributes, Volatile Profile and Sensory Quality of Organic Crimson Crisp Apples during On-Tree Maturation.Foods (Basel, Switzerland) · 2023Article
- Biocatalytic Approach for Direct Esterification of Ibuprofen with Sorbitol in Biphasic Media.International journal of molecular sciences · 2021Article
- Shotgun proteomics of peach fruit reveals major metabolic pathways associated to ripening.BMC genomics · 2021Article
- Ultra-high throughput single-cell analysis of proteins and RNAs by split-pool synthesis.Communications biology · 2020Article
- Health effects of kiwi wine on rats: an untargeted metabolic fingerprint study based on GC-MS/TOF.RSC advances · 2019Article
- Impact of Within-Tree Organ Distances on Floral Induction and Fruit Growth in Apple Tree: Implication of Carbohydrate and Gibberellin Organ Contents.Frontiers in plant science · 2019Article
- Red to Brown: An Elevated Anthocyanic Response in Apple Drives Ethylene to Advance Maturity and Fruit Flesh Browning.Frontiers in plant science · 2019Article
- Discovery and Functional Characterization of a Yeast Sugar Alcohol Phosphatase.ACS chemical biology · 2018Article
- Photosynthetic limitation as a factor influencing yield in highbush blueberries (Vaccinium corymbosum) grown in a northern European environment.Journal of experimental botany · 2018Article
- Increased activity of MdFRK2, a high-affinity fructokinase, leads to upregulation of sorbitol metabolism and downregulation of sucrose metabolism in apple leaves.Horticulture research · 2018Article
- Sugar metabolism and accumulation in the fruit of transgenic apple trees with decreased sorbitol synthesis.Horticulture research · 2018Article
- Sugar metabolism reprogramming in a non-climacteric bud mutant of a climacteric plum fruit during development on the tree.Journal of experimental botany · 2017Article
- Chromatin-associated regulation of sorbitol synthesis in flower buds of peach.Plant molecular biology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sorbitol and sucrose are major products of photosynthesis distributed in apple trees (Malus domestica Borkh. cv. "Greensleeves") that affect quality in fruit. Transgenic apple plants were silenced or up-regulated for sorbitol-6-phosphate dehydrogenase by using the CaMV35S promoter to define the role of sorbitol distribution in fruit development. Transgenic plants with suppressed sorbitol-6-phosphate dehydrogenase compensated by accumulating sucrose and starch in leaves, and morning and midday net carbon assimilation rates were significantly lower. The sorbitol to sucrose ratio in leaves was reduced by approximately 90% and in phloem exudates by approximately 75%. The fruit accumulated more glucose and less fructose, starch, and malic acid, with no overall differences in weight and firmness. Sorbitol dehydrogenase activity was reduced in silenced fruit, but activities of neutral invertase, vacuolar invertase, cell wall-bound invertase, fructose kinase, and hexokinase were unaffected. Analyses of transcript levels and activity of enzymes involved in carbohydrate metabolism throughout fruit development revealed significant differences in pathways related to sorbitol transport and breakdown. Together, these results suggest that sorbitol distribution plays a key role in fruit carbon metabolism and affects quality attributes such as sugar-acid balance and starch accumulation.
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