ArticleBlood2007
A novel human B cell subpopulation representing the initial germinal center population to express AID.
Article in Blood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Associations between immune cell traits and autoimmune thyroid diseases: a bidirectional two-sample mendelian randomization study.Immunogenetics · 2024Article
- Ancestral reconstruction reveals catalytic inactivation of activation-induced cytidine deaminase concomitant with cold water adaption in the Gadiformes bony fish.BMC biology · 2022Article
- Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ-on-a-Chip.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Committed Human CD23-Negative Light-Zone Germinal Center B Cells Delineate Transcriptional Program Supporting Plasma Cell Differentiation.Frontiers in immunology · 2021Article
- Metabolic defects in splenic B cell compartments from patients with liver cirrhosis.Cell death & disease · 2020Article
- B Cell Receptor Immunogenetics in B Cell Lymphomas: Immunoglobulin Genes as Key to Ontogeny and Clinical Decision Making.Frontiers in oncology · 2020Review
- Challenges and Opportunities for Consistent Classification of Human B Cell and Plasma Cell Populations.Frontiers in immunology · 2019Review
- Article
- Impaired B cell immunity in acute myeloid leukemia patients after chemotherapy.Journal of translational medicine · 2017Article
- Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage.Cancer cell · 2016Article
- Dysregulated B-cell TLR2 expression and elevated regulatory B-cell frequency precede the diagnosis of AIDS-related non-Hodgkin lymphoma.AIDS (London, England) · 2015Article
- Immune Activation: Contribution to AIDS-Associated Non-Hodgkin Lymphoma.Forum on immunopathological diseases and therapeutics · 2015Article
- Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas.Nature medicine · 2014Article
- Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest.PloS one · 2014Article
- Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biologic and clinical features.Cancer research · 2012Article
- Molecular pathogenesis of mantle cell lymphoma.The Journal of clinical investigation · 2012Review
- Activation of B cells by non-canonical helper signals.EMBO reports · 2012Review
- New helping friends for B cells.European journal of immunology · 2012Review
- Advances in human B cell phenotypic profiling.Frontiers in immunology · 2012Article
- Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component.The American journal of surgical pathology · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We have identified a novel mature human B-cell subpopulation in the human tonsil that has characteristics of both naive B cells and germinal center B cells including the expression of activation-induced cytidine deaminase (AID), which is essential for the process of immunoglobulin somatic hypermutation and class-switch recombination. These cells are clearly somatically hypermutated, albeit modestly. Their phenotype (IgD(+)CD38(-)CD23(-)FSC(hi)CD71(+)) is unique and suggests they may be intermediate between both naive and germinal center cells. Morphologically they are also distinct from other B-cell subpopulations. The evidence presented suggests these cells may be the founder cells of the germinal center reaction (a pro-GC cell) and may be the normal counterpart of the mantle cell lymphoma cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.