Trial reportThe British journal of general practice : the journal of the Royal College of General Practitioners2006
Hepatitis C infection among injecting drug users in general practice: a cluster randomised controlled trial of clinical guidelines' implementation.
Trial report in The British journal of general practice : the journal of the Royal College of General Practitioners, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Hepatitis C Infection and Treatment among Injecting Drug Users Attending General Practice: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- What Are the Self-Assessed Training Needs of Early Career Professionals in Addiction Medicine? A BEME Focused Review.MedEdPublish (2016) · 2020Pooled it
- Evidence-based interventions to enhance assessment, treatment, and adherence in the chronic Hepatitis C care continuum.The International journal on drug policy · 2015Pooled it
- Targeted hepatitis C antibody testing interventions: a systematic review and meta-analysis.European journal of epidemiology · 2015Pooled it
- Cost effectiveness of an intervention to increase uptake of hepatitis C virus testing and treatment (HepCATT): cluster randomised controlled trial in primary care.BMJ (Clinical research ed.) · 2020Trial
- Integrating Hepatitis C Care for Opioid Substitution Treatment Patients Attending General Practice: Feasibility, Clinical, and Cost-Effectiveness Analysis.Interactive journal of medical research · 2022Article
- On-site testing and case management to improve hepatitis C care in drug users: a prospective, longitudinal, multicenter study in the DAA era.BMC public health · 2021Article
- Impact of routine opt-out HIV/HCV screening on testing uptake at a syringe services program: An interrupted time series analysis.The International journal on drug policy · 2020Article
- Increasing uptake of hepatitis C virus infection case-finding, testing, and treatment in primary care: evaluation of the HepCATT (Hepatitis C Assessment Through to Treatment) trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2020Article
- Hepatitis C virus infection in Irish drug users and prisoners - a scoping review.BMC infectious diseases · 2019Article
- Evidence-based and guideline-concurrent responses to narratives deferring HCV treatment among people who inject drugs.Harm reduction journal · 2019Article
- Hepatitis C elimination among people who inject drugs: Challenges and recommendations for action within a health systems framework.Liver international : official journal of the International Association for the Study of the Liver · 2019Review
- Integrated Hepatitis C Care for People Who Inject Drugs (Heplink): Protocol for a Feasibility Study in Primary Care.JMIR research protocols · 2018Article
- Detecting Hepatitis B and C by Combined Public Health and Primary Care Birth Cohort Testing.Annals of family medicine · 2018Article
- Direct-acting antiviral agents for HCV infection affecting people who inject drugs.Nature reviews. Gastroenterology & hepatology · 2017Review
- Barriers and facilitators to implementing addiction medicine fellowships: a qualitative study with fellows, medical students, residents and preceptors.Addiction science & clinical practice · 2017Article
- Research priorities to achieve universal access to hepatitis C prevention, management and direct-acting antiviral treatment among people who inject drugs.The International journal on drug policy · 2017Article
- Eligibility of persons who inject drugs for treatment of hepatitis C virus infection.World journal of gastroenterology · 2014Review
- Case-finding for hepatitis C in primary care: a mixed-methods service evaluation.The British journal of general practice : the journal of the Royal College of General Practitioners · 2014Article
- Psychosocial interventions for alcohol use among problem drug users: protocol for a feasibility study in primary care.JMIR research protocols · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatitis C is a common infection among injecting drug users and has important implications for general practice. Although several clinical guidelines concerning the infection have been published, their effectiveness has yet to be tested.
aimTo assess the effectiveness of a general practice-based complex intervention to support the implementation of clinical guidelines for hepatitis C management among current or former drug users attending general practice. DESIGN OF STUDY: Cluster randomised controlled trial.
settingGeneral practices in the Eastern Regional Health Authority area of Ireland.
methodTwenty-six practices were randomly allocated within strata to receive the intervention under study or to provide care as usual for a period of 6 months. There was screening for patients attending general practice for methadone maintenance treatment for hepatitis C and referral of anti-HCV antibody positive patients to a specialist hepatology department for assessment.
resultsAt study completion, patients in the intervention group were significantly more likely to have been screened for hepatitis C than those in the control group, odds ratio adjusted for clustering 3.76 (95% confidence interval [CI] = 1.3 to 11.3) and this association remained significant after adjusting for other potentially confounding variables, using multiple logistic regression, with the odds ratio adjusted for clustering 4.53 (95% CI = 1.39 to 14.78). Although anti-HCV antibody positive patients in the intervention group were more likely to have been referred to a hepatology clinic, this was not statistically significant (P = 0.06).
conclusionGeneral practice has an important role in the care of people at risk of hepatitis C and when appropriately supported can effectively implement current best practice.
Indexed as
Identifiers
17132352PMC1927093W1735166017What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.