ArticleBehavioral and brain functions : BBF2006
Haloperidol treatment induces tissue- and sex-specific changes in DNA methylation: a control study using rats.
Article in Behavioral and brain functions : BBF, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- DNA methylation and histone modifications associated with antipsychotic treatment: a systematic review.Molecular psychiatry · 2025Pooled it
- Sex-specific DNA methylation differences in Alzheimer's disease pathology.Acta neuropathologica communications · 2021Pooled it
- DNA Methylation as a Biomarker of Treatment Response Variability in Serious Mental Illnesses: A Systematic Review Focused on Bipolar Disorder, Schizophrenia, and Major Depressive Disorder.International journal of molecular sciences · 2018Pooled it
- Accelerated aging in schizophrenia: integrating epigenetic clocks, telomere dynamics, senescence-associated secretory phenotype, and oxidative stress.European archives of psychiatry and clinical neuroscience · 2026Review
- Drug-induced liver injury associated with atypical generation antipsychotics from the FDA Adverse Event Reporting System (FAERS).BMC pharmacology & toxicology · 2024Article
- Molecular mechanisms of antipsychotics - their influence on intracellular signaling pathways, and epigenetic and post-transcription processes.Postepy psychiatrii neurologii · 2022Review
- Risperidone Induced DNA Methylation Changes in Dopamine Receptor and Stathmin Genes in Mice Exposed to Social Defeat Stress.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022Article
- Article
- Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain.Development and psychopathology · 2016Review
- From Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of Schizophrenia.Frontiers in neuroscience · 2016Review
- Mood Stabilizers and the Influence on Global Leukocyte DNA Methylation in Bipolar Disorder.Molecular neuropsychiatry · 2015Article
- The diet-induced metabolic syndrome is accompanied by whole-genome epigenetic changes.Genes & nutrition · 2015Article
- Potential molecular and cellular mechanism of psychotropic drugs.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2014Review
- Whole genome methylation analyses of schizophrenia patients before and after treatment.Biotechnology, biotechnological equipment · 2014Article
- The future of neuroepigenetics in the human brain.Progress in molecular biology and translational science · 2014Review
- Age-associated decrease in global DNA methylation in patients with major depression.Neuropsychiatric disease and treatment · 2014Article
- Plasma total homocysteine is associated with DNA methylation in patients with schizophrenia.Epigenetics · 2013Article
- DNA methylation signatures of peripheral leukocytes in schizophrenia.Neuromolecular medicine · 2013Article
- Epigenetics in the human brain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe previously found that there is a subtle difference in the global methylation state of blood leukocyte DNA between male subjects with and without schizophrenia. The aim of the current study was to determine whether this difference was a primary effect of the disease state, or a secondary effect of antipsychotics administered to these patients.
methodsWe examined the methyl cytosine (mC) content of DNA from the leukocytes, brain, and liver of rats using high performance liquid chromatography. A total of 40 male and female rats received for 21 days daily injection of haloperidol or vehicle solution alone.
resultsIn control rats injected with buffer only, there was a sex-dependent difference in mC content in leukocyte DNA (male > female; P = 0.028, n = 10), similar to our previous observations in human peripheral leukocytes. No difference in mC content between the sexes was observed in the brain or liver in buffer-treated animals. Haloperidol treatment slightly decreased the mC content of leukocytes in male rats, but unexpectedly, increased the mC content of leukocytes in females. We observed a trend toward a higher level of mC in the liver in both sexes following haloperidol treatment, compared to buffer-treated animals. In contrast, haloperidol treatment resulted in a decrease in mC content in the brain in females, and this difference was statistically significant (P = 0.026).
conclusionThese results indicate that haloperidol can affect DNA methylation states in the brain, as well as in certain other tissues, and raise the possibility that antipsychotic drugs play a role in the observed disparity in mC content in male subjects with and without schizophrenia.
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Registered trials
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