Evidence map›Paper›PMID 17131989›Full record

ArticleJournal of the American Chemical Society2006

Unexpected acetylcholinesterase activity of cocaine esterases.

Claude J Rogers, Lisa M Eubanks, Tobin J Dickerson, Kim D Janda

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Claude J RogersDepartment of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Lisa M Eubanks
Tobin J Dickerson
Kim D Janda
Scripps Research Institute · US

Funding

Immunopharmacotherapy for the Treatment of Cocaine AbuseR01DA008590 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI JANDA, KIM · 1994 to 2016
$6.4M
A new protein-based approach for cocaine abuse treatmentR21DA017228 · NIDA · SCRIPPS RESEARCH INSTITUTE · PI JANDA, KIM D · 2003 to 2004
$375k
NIDA NIH HHS DA 08590NIDA NIH HHS DA 17228NIDA NIH HHS R01 DA008590NIDA NIH HHS R21 DA017228
6 · The paper itself

Abstract

A series of proteins with cocaine esterase ability have been shown to hydrolyze acetylcholine with similar rate enhancements. Docking studies revealed that acetylcholine binds in a similar orientation as cocaine. These results suggest that acetylcholinesterase activity may be inherent to cocaine esterases.

Indexed as

AcetylcholinesteraseAntibodies, CatalyticAntibodies, MonoclonalBinding SitesCarboxylic Ester HydrolasesCatalysisCocaineCocaine-Related DisordersCrystallographyHumansHydrolysisModels, MolecularSubstrate SpecificityAcetylcholinesteraseAntibodies, CatalyticAntibodies, MonoclonalCarboxylic Ester HydrolasesCocainecocaine esterase

Identifiers

PMID17131989
PMCPMC2533137
OpenAlexW1974838237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.