ArticleInfection and immunity1991
Immunological characterization of recombinant antigens isolated from a Mycobacterium avium lambda gt11 expression library by using monoclonal antibody probes.
Article in Infection and immunity, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Feature of Adhesins Produced by Human Clinical Isolates ofMicroorganisms · 2020Article
- Novel feature of Mycobacterium avium subsp. paratuberculosis, highlighted by characterization of the heparin-binding hemagglutinin adhesin.Journal of bacteriology · 2013Article
- The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis.Infection and immunity · 2004Article
- Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Mycobacterial protein HbhA binds human complement component C3.Infection and immunity · 2001Article
- Functional domains present in the mycobacterial hemagglutinin, HBHA.Journal of bacteriology · 1999Article
- Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Molecular and immunological analyses of the Mycobacterium avium homolog of the immunodominant Mycobacterium leprae 35-kilodalton protein.Infection and immunity · 1998Article
- Identification of epitopes of fibronectin attachment protein (FAP-A) of Mycobacterium avium which stimulate strong T-cell responses in mice.Infection and immunity · 1998Article
- Processing and presentation of an antigen of Mycobacterium avium require access to an acidified compartment with active proteases.Infection and immunity · 1996Article
- Identification of a heparin-binding hemagglutinin present in mycobacteria.The Journal of experimental medicine · 1996Article
- Rapid detection of Mycobacterium avium in stool samples from AIDS patients by immunomagnetic PCR.Journal of clinical microbiology · 1996Article
- Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.Antimicrobial agents and chemotherapy · 1995Article
- Nucleotide sequence analysis and serologic characterization of a 27-kilodalton Mycobacterium intracellulare lipoprotein.Infection and immunity · 1993Article
- Mycobacterium avium complex disease in patients with AIDS: seroreactivity to native and recombinant mycobacterial antigens.Journal of clinical microbiology · 1991Article
- Antigens of the Mycobacterium avium, Mycobacterium intracellulare complex.European journal of epidemiology · 1991Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nontuberculous mycobacteria, particularly Mycobacterium avium, have been isolated from a significant percentage of patients with AIDS. Early detection of M. avium infection is difficult, and treatment regimens are often ineffective. Much needs to be learned about antigens and factors responsible for immunity to and pathogenesis of the disease. Specific antigens and diagnostic procedures for infection need to be developed. To address some of these problems, we have generated 25 different monoclonal antibodies against a serovar 4 strain of M. avium isolated from a patient with AIDS. Protease sensitivity studies have demonstrated that each of these antibodies recognizes a protein-associated epitope. Immunoblot analyses suggest that seven of these monoclonal antibodies react specifically with M. avium and M. intracellular epitopes. Immunoreactive bacteriophages were identified from an M. avium lambda gt11 expression library with two of these monoclonal antibodies (3808 C3 and 3954 B12). Lambda lysogens, generated from the immunoreactive bacteriophages, overproduced beta-galactosidase fusion proteins which were reactive with the two monoclonal antibodies in immunoblot assays. The purified fusion proteins were shown to elicit skin test reactions in sensitized guinea pigs.
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