ArticleEuropean archives of psychiatry and clinical neuroscience2007
Gonadal axis hormones in psychiatric male patients after a suicide attempt.
Article in European archives of psychiatry and clinical neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Anabolic-androgenic steroid use and psychopathology in athletes. A systematic review.Current neuropharmacology · 2015Pooled it
- Executive performance of depressed suicide attempters: the role of suicidal ideation.European archives of psychiatry and clinical neuroscience · 2008Trial
- Exploring the risk of depression and suicide/self-injury in patients receiving GLP-1RAs combined with metformin versus GLP-1RA monotherapy: a real-word analysis of the FAERS database.Endocrine connections · 2026Article
- Serum folate and homocysteine as biomarkers for suicide risk in major depressive disorder: insights in males and younger patients.BMC psychiatry · 2025Observational
- Sex differences in the association between suicidal ideation and neurocognitive function in Chinese patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2024Article
- Article
- Testosterone and Suicidal Behavior in Bipolar Disorder.International journal of environmental research and public health · 2023Article
- Psychobiological risk factors for suicidal thoughts and behaviors in adolescence: a consideration of the role of puberty.Molecular psychiatry · 2022Review
- New frontiers in suicide vulnerability: immune system and sex hormones.Brain, behavior, & immunity - health · 2021Article
- Aggressive behavior in psychiatric patients in relation to hormonal imbalance (Review).Experimental and therapeutic medicine · 2020Review
- Lipids and Suicide Risk.Current topics in behavioral neurosciences · 2020Article
- Role of HPA and the HPG Axis Interaction in Testosterone-Mediated Learned Helpless Behavior.Molecular neurobiology · 2019Article
- Is cannabis a risk factor for suicide attempts in men and women with psychotic illness?Psychopharmacology · 2018Article
- Sex Differences in Neurotoxicogenetics.Frontiers in genetics · 2018Review
- Animal models to improve our understanding and treatment of suicidal behavior.Translational psychiatry · 2017Review
- Commentary: CSF and Plasma Testosterone in Attempted Suicide.Frontiers in public health · 2017Article
- Commentary: Exogenous Testosterone Rapidly Increases Aggressive Behavior in Dominant and Impulsive Men.Frontiers in public health · 2016Article
- Association of testosterone levels and future suicide attempts in females with bipolar disorder.Journal of affective disorders · 2014Article
- Article
- Testosterone levels in suicide attempters with bipolar disorder.Journal of psychiatric research · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological and clinical studies support the view that aggressive acts like suicidal and violent behaviors share a common substrate. Certain aspects of violence in males have been related to high testosterone levels, but the relation of testosterone to attempted suicide has not been studied until now. We estimated plasma levels of testosterone (T), LH, and FSH in 80 male subjects after a suicide attempt and in whom a psychiatric assessment was done during their hospitalization. Suicide intent was evaluated in 72 subjects. A group of 56 healthy males in the same age range served as control. As a group, attempters showed significantly lower T levels, marginally higher LH, and normal FSH compared to controls. The attempters who used violent methods (26 subjects) had T levels even lower than the non-violent (drug overdose) subgroup. Comparisons of T levels of subgroups according to the (main) drug ingested (analgesics, benzodiazepines, antidepressants, neuroleptics, or other drugs) did not reveal any significant drug effect. In relation to diagnosis, the lowest T levels were found in the subgroup with schizophrenia (29 subjects). The T levels of this subgroup were also significantly lower compared to those of a group of 31 male schizophrenic patients, hospitalized and treated with neuroleptics. If the influence of post-attempt stress and medical condition on plasma T could be ruled out, low plasma T may prove to be a biological predictor of attempt, at least in male schizophrenic patients. Nevertheless, the findings differentiate suicidal behavior from other aggressive/violent behaviors and do not support the notion that suicidal and aggressive behaviors are manifestations of the same impulse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.