ArticleMolecular systems biology2006
Communication between levels of transcriptional control improves robustness and adaptivity.
Article in Molecular systems biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Proteomic consequences of TDA1 deficiency in Saccharomyces cerevisiae: Protein kinase Tda1 is essential for Hxk1 and Hxk2 serine 15 phosphorylation.Scientific reports · 2022Article
- Identification of the Target of the Retrograde Response that Mediates Replicative Lifespan Extension in Saccharomyces cerevisiae.Genetics · 2016Article
- Stochastic control of proliferation and differentiation in stem cell dynamics.Journal of mathematical biology · 2015Article
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- A system based network approach to ethanol tolerance in Saccharomyces cerevisiae.BMC systems biology · 2014Article
- Genome-wide analysis of functional sirtuin chromatin targets in yeast.Genome biology · 2013Article
- Principles of regulation of self-renewing cell lineages.PloS one · 2013Article
- Article
- Stochastic modeling of stem-cell dynamics with control.Mathematical biosciences · 2012Article
- Systematic dissection of roles for chromatin regulators in a yeast stress response.PLoS biology · 2012Article
- Chromosomal position effects are linked to sir2-mediated variation in transcriptional burst size.Biophysical journal · 2011Article
- Dot1 and histone H3K79 methylation in natural telomeric and HM silencing.Molecular cell · 2011Article
- Dynamics of Sir3 spreading in budding yeast: secondary recruitment sites and euchromatic localization.The EMBO journal · 2011Article
- The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersion.Genome research · 2009Article
- Cell lineages and the logic of proliferative control.PLoS biology · 2009Article
- Stochastic and regulatory role of chromatin silencing in genomic response to environmental changes.PloS one · 2008Article
- Associating transcription factor-binding site motifs with target GO terms and target genes.Nucleic acids research · 2008Article
- Immobility, inheritance and plasticity of shape of the yeast nucleus.BMC cell biology · 2007Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulation of eukaryotic gene expression depends on groups of related proteins acting at the levels of chromatin organization, transcriptional initiation, RNA processing, and nuclear transport. However, a unified understanding of how these different levels of transcriptional control interact has been lacking. Here, we combine genome-wide protein-DNA binding data from multiple sources to infer the connections between functional groups of regulators in Saccharomyces cerevisiae. Our resulting transcriptional network uncovers novel biological relationships; supporting experiments confirm new associations between actively transcribed genes and Sir2 and Esc1, two proteins normally linked to silencing chromatin. Analysis of the regulatory network also reveals an elegant architecture for transcriptional control. Using communication theory, we show that most protein regulators prefer to form modules within their functional class, whereas essential proteins maintain the sparse connections between different classes. Moreover, we provide evidence that communication between different regulatory groups improves the robustness and adaptivity of the cell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.