ArticleProceedings of the National Academy of Sciences of the United States of America2006
A driving and coupling "Pac-Man" mechanism for chromosome poleward translocation in anaphase A.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism.Nature communications · 2021Article
- Electrostatic forces drive poleward chromosome motions at kinetochores.Cell division · 2016Article
- Directed and persistent movement arises from mechanochemistry of the ParA/ParB system.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Accurate phosphoregulation of kinetochore-microtubule affinity requires unconstrained molecular interactions.The Journal of cell biology · 2014Article
- Highly Transient Molecular Interactions Underlie the Stability of Kinetochore-Microtubule Attachment During Cell Division.Cellular and molecular bioengineering · 2013Article
- Filament depolymerization can explain chromosome pulling during bacterial mitosis.PLoS computational biology · 2011Article
- Can molecular cell biology explain chromosome motions?Theoretical biology & medical modelling · 2011Article
- The Dam1 ring binds to the E-hook of tubulin and diffuses along the microtubule.Molecular biology of the cell · 2011Article
- Kinetochores' gripping feat: conformational wave or biased diffusion?Trends in cell biology · 2011Review
- Kinetochore-microtubule interactions: steps towards bi-orientation.The EMBO journal · 2010Review
- The perpetual movements of anaphase.Cellular and molecular life sciences : CMLS · 2010Review
- Force transduction by the microtubule-bound Dam1 ring.Biophysical journal · 2010Article
- Structure-function insights into the yeast Dam1 kinetochore complex.Journal of cell science · 2009Review
- Bi-orienting chromosomes: acrobatics on the mitotic spindle.Chromosoma · 2008Review
- The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motion.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- An integrated mechanobiochemical feedback mechanism describes chromosome motility from prometaphase to anaphase in mitosis.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Kinetochore-microtubule interactions: the means to the end.Current opinion in cell biology · 2008Review
- In search of an optimal ring to couple microtubule depolymerization to processive chromosome motions.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- A mechanobiochemical mechanism for monooriented chromosome oscillation in mitosis.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During mitosis, chromatid harnesses its kinetochore translocation at the depolymerizing microtubule ends for its poleward movement in anaphase A. The force generation mechanism for such movement remains unknown. Analysis of the current experimental results shows that the bending energy release from the bound tubulin subunits alone cannot provide sufficient driving force. Additional contribution from effective electrostatic attractions between the kinetochore and the microtubule is needed for kinetochore translocation. Interestingly, as the kinetochore moves to inside the microtubule, the microtubule tip is free to bend outward so that the instantaneous distance between the kinetochore and the microtubule tip is much closer than the rest of the microtubule. This close contact yields much larger electrostatic attraction than that from the rest of the microtubule under physiological ionic conditions. As a result, the effective electrostatic interaction hinders the further kinetochore poleward translocation until the microtubule tip dissociates. Thus, the kinetochore translocation is strongly coupled at the depolymerizing microtubule end. This driving-coupling mechanism indicates that the kinetochore velocity is largely controlled by the microtubule dissociation rate, which explains the insensitivity of kinetochore velocity to its viscous drag and the large redundancy in its stalling force.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.