ArticleThe American journal of pathology1991
Unexpected immunoreactivities of intermediate filament antibodies in human brain and brain tumors.
Article in The American journal of pathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 81 citations in OpenAlex.
- A 79-Year-Old Woman With Headache and Acromegaly.Brain pathology (Zurich, Switzerland) · 2020Article
- Purification of mitochondrial proteins HSP60 and ATP synthase from ascidian eggs: implications for antibody specificity.PloS one · 2013Article
- Prognostic significance of neuronal marker expression in glioblastomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Article
- Functional role for interleukin-1 in the injured peripheral taste system.Journal of neuroscience research · 2012Article
- Comparative study of Pax2 expression in glial cells in the retina and optic nerve of birds and mammals.The Journal of comparative neurology · 2010Article
- Differential distribution of erbB receptors in human glioblastoma multiforme: expression of erbB3 in CD133-positive putative cancer stem cells.Journal of neuropathology and experimental neurology · 2010Article
- Phosphorylation of extracellular signal-regulated kinases in bladder afferent pathways with cyclophosphamide-induced cystitis.Neuroscience · 2009Article
- Astroglia in medullary dorsal horn (trigeminal spinal subnucleus caudalis) are involved in trigeminal neuropathic pain mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Sall3 is required for the terminal maturation of olfactory glomerular interneurons.The Journal of comparative neurology · 2008Article
- Secondary glioblastoma with advanced neuronal immunophenotype.Virchows Archiv : an international journal of pathology · 2005Article
- Unchanged packing density but altered size of neurofilament immunoreactive neurons in the prefrontal cortex in schizophrenia and major depression.Schizophrenia research · 2005Article
- Brain dystrophin-glycoprotein complex: persistent expression of beta-dystroglycan, impaired oligomerization of Dp71 and up-regulation of utrophins in animal models of muscular dystrophy.BMC cell biology · 2001Article
- Subependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosis.The American journal of pathology · 1997Article
- Cytokeratin 8 released by breast carcinoma cells in vitro binds plasminogen and tissue-type plasminogen activator and promotes plasminogen activation.The Biochemical journal · 1996Article
- Expression of neurofilaments and of a titin epitope in thymic epithelial tumors. Implications for the pathogenesis of myasthenia gravis.The American journal of pathology · 1996Article
- Primary leiomyosarcoma of the spinal leptomeninges.Journal of neuro-oncology · 1994Article
- A morphological and immunohistochemical study of human retinal pigment epithelial cells, retinal glia, and fibroblasts grown on Gelfoam matrix in an organ culture system. A comparison of structural and nonstructural proteins and their application to cell type identification.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 1993Article
- Rosenthal fibers producing a granular cell appearance in a glioblastoma.Acta neuropathologica · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunoreactivities of 35 different monoclonal antibodies (MAbs) that detect intermediate filaments were studied systematically on serial cryostat sections of 14 well-defined human gliomas (five astrocytomas, three oligodendrogliomas, six glioblastomas) and on normal brain. Glial fibrillary acidic protein (GFAP), vimentin, desmin, neurofilaments, and broad-specificity keratin MAbs, as well as MAbs that recognize several or only single keratin polypeptides, were used. Unexpected reactivities were surprisingly frequent. As these may lead to diagnostic confusion and misinterpretation on this material, the authors investigated these phenomena more thoroughly. Four major sources of artifactual staining were found: 1) positive staining attributable to the rabbit gamma G immunoglobulins used in the alkaline phosphatase anti-alkaline phosphatase technique; 2) certain desmin and keratin MAbs cross-reacted with astrocytic glia and with other brain-specific epitopes; 3) technical difficulties; 4) some MAbs directed against neurofilaments and keratins showed unexpected reactivities only on individual anaplastic gliomas. The implications of these findings for intermediate filament typing of neuropathologic material are discussed.
Indexed as
Identifiers
1713022PMC1886144W1689843645What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.