ArticleNucleic acids research2006
Sequence-dependent gating of an ion channel by DNA hairpin molecules.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Through the holes: the biotechnological potential of actinoporins (and other PFPs).Biophysical reviews · 2026Review
- Complex and Non-sequential Current Signatures of a β-Hairpin Peptide Confined in a Nanopore.Analytical chemistry · 2025Article
- Single-molecule profiling of per- and polyfluoroalkyl substances by cyclodextrin mediated host-guest interactions within a biological nanopore.Science advances · 2024Article
- Single molecule technique unveils the role of electrostatic interactions in ssDNA-gp32 molecular complex stability.RSC advances · 2024Article
- Antimicrobial Activity of Quercetin, Naringenin and Catechin: Flavonoids InhibitMolecules (Basel, Switzerland) · 2023Article
- Recent Advances in Liposome-Based Molecular Robots.Micromachines · 2020Review
- α-Hemolysin nanopore studies reveal strong interactions between biogenic polyamines and DNA hairpins.Mikrochimica acta · 2016Article
- Base Flipping within the α-Hemolysin Latch Allows Single-Molecule Identification of Mismatches in DNA.Journal of the American Chemical Society · 2016Article
- Internal vs fishhook hairpin DNA: unzipping locations and mechanisms in the α-hemolysin nanopore.The journal of physical chemistry. B · 2014Article
- Nanopore biosensor for label-free and real-time detection of anthrax lethal factor.ACS applied materials & interfaces · 2014Article
- Creating a Single Sensing Zone within an Alpha-Hemolysin Pore Via Site Directed Mutagenesis.BioNanoScience · 2014Article
- Detection of 3'-end RNA uridylation with a protein nanopore.ACS nano · 2014Article
- Nanopore analysis of wild-type and mutant prion protein (PrP(C)): single molecule discrimination and PrP(C) kinetics.PloS one · 2013Article
- Unzipping kinetics of duplex DNA containing oxidized lesions in an α-hemolysin nanopore.Journal of the American Chemical Society · 2012Article
- Origins and consequences of velocity fluctuations during DNA passage through a nanopore.Biophysical journal · 2011Article
- Shrinking of Solid-state Nanopores by Direct Thermal Heating.Nanoscale research letters · 2011Article
- Polymer translocation through alpha-hemolysin pore with tunable polymer-pore electrostatic interaction.The Journal of chemical physics · 2010Article
- Urea facilitates the translocation of single-stranded DNA and RNA through the alpha-hemolysin nanopore.Biophysical journal · 2010Article
- Monitoring the escape of DNA from a nanopore using an alternating current signal.Journal of the American Chemical Society · 2010Article
- Duration learning for analysis of nanopore ionic current blockades.BMC bioinformatics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
DNA hairpins produce ionic current signatures when captured by the alpha-hemolysin nano-scale pore under conditions of single molecule electrophoresis. Gating patterns produced by individual DNA hairpins when captured can be used to distinguish differences of a single base pair or even a single nucleotide [Vercoutere,W.A. et al. (2003) Nucleic Acids Res., 31, 1311-1318]. Here we investigate the mechanism(s) that may account for the ionic current gating signatures. The ionic current resistance profile of conductance states produced by DNA hairpin molecules with 3-12 bp stems showed a plateau in resistance between 10 and 12 bp, suggesting that hairpins with 10-12 bp stems span the pore vestibule. DNA hairpins with 9-12 bp stems produced gating signatures with the same relative conductance states. Systematic comparison of the conductance state dwell times and apparent activation energies for a series of 9-10 bp DNA hairpins suggest that the 3' and 5' ends interact at or near the limiting aperture within the vestibule of the alpha-hemolysin pore. The model presented may be useful in predicting and interpreting DNA detection using nanopore detectors. In addition, this well-defined molecular system may prove useful for investigating models of ligand-gated channels in biological membranes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.