ArticleNucleic acids research2006
Transcriptional regulation of the cyclin-dependent kinase inhibitor 1A (p21) gene by NFI in proliferating human cells.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 68 citations in OpenAlex.
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- Ionising radiation exposure-induced regulation of selected biomarkers and their impact in cancer and treatment.Frontiers in nuclear medicine · 2024Review
- NFIB facilitates replication licensing by acting as a genome organizer.Nature communications · 2023Article
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- Inhibition of Autophagy Promotes the Anti-Tumor Effect of Metformin in Oral Squamous Cell Carcinoma.Cancers · 2022Article
- NFI-C Is Required for Epiphyseal Chondrocyte Proliferation during Postnatal Cartilage Development.Molecules and cells · 2020Article
- Overexpression of p21 Has Inhibitory Effect on Human Hematopoiesis by Blocking Generation of CD43＋ Cells via Cell-Cycle Regulation.International journal of stem cells · 2020Article
- Irradiated Human Fibroblasts as a Substitute Feeder Layer to Irradiated Mouse 3T3 for the Culture of Human Corneal Epithelial Cells: Impact on the Stability of the Transcription Factors Sp1 and NFI.International journal of molecular sciences · 2019Article
- Responses ofMolecules (Basel, Switzerland) · 2019Article
- Association of genetic variation of the six gene prognostic model for castration-resistant prostate cancer with survival.The Prostate · 2019Article
- Nuclear Factor I Represses the Notch Effector HEY1 in Glioblastoma.Neoplasia (New York, N.Y.) · 2018Article
- Nfia deletion in myeloid cells blocks expansion of myeloid-derived suppressor cells during sepsis.Innate immunity · 2018Article
- Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells.International journal of oncology · 2017Article
- Article
- The role of nuclear factor I-C in tooth and bone development.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2017Review
- NFI-A disrupts myeloid cell differentiation and maturation in septic mice.Journal of leukocyte biology · 2016Article
- New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor.Oncotarget · 2015Article
- MicroRNA 21 (miR-21) and miR-181b couple with NFI-A to generate myeloid-derived suppressor cells and promote immunosuppression in late sepsis.Infection and immunity · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cyclin-dependent kinase inhibitor 1A (CDKN1A), also known as p21 (WAF1/CIP1) modulates cell cycle, apoptosis, senescence and differentiation via specific protein-protein interactions with the cyclins, cyclin-dependent kinase (Cdk), and many others. Expression of the p21 gene is mainly regulated at the transcriptional level. By conducting both ligation-mediated PCR (LMPCR) and chromatin immunoprecipitation (ChIP) in vivo, we identified a functional target site for the transcription factor, nuclear factor I (NFI), in the basal promoter from the p21 gene. Transfection of recombinant constructs bearing mutations in the p21 NFI site demonstrated that NFI acts as a repressor of p21 gene expression in various types of cultured cells. Inhibition of NFI in human skin fibroblasts through RNAi considerably increased p21 promoter activity suggesting that NFI is a key repressor of p21 transcription. Over-expression of each of the four NFI isoforms in HCT116 cells established that each of them contribute to various extend to the repression of the p21 gene. Most of all, over-expression of NFI-B in doxorubicin, growth-arrested HCT116 increased the proportion of cells in the S-phase of the cell cycle whereas NFI-A and NFI-X reduced it, thereby establishing a role for NFI in the cell cycle dependent expression of p21.
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Registered trials
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