ArticleGut2007
Branch-duct intraductal papillary mucinous neoplasms of the pancreas: to operate or not to operate?
Article in Gut, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
88 citing papers in PubMed, 5 syntheses or guidelines pooled it, 261 citations in OpenAlex.
- Imaging Features for Predicting High-Grade Dysplasia or Malignancy in Branch Duct Type Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Systematic Review and Meta-Analysis.Annals of surgical oncology · 2022Pooled it
- Serum Carbohydrate Antigen 19-9 in Differential Diagnosis of Benign and Malignant Pancreatic Cystic Neoplasms: A Meta-Analysis.PloS one · 2016Pooled it
- Utility of the sendai consensus guidelines for branch-duct intraductal papillary mucinous neoplasms: a systematic review.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2014Pooled it
- Management of mucinous cystic neoplasms of the pancreas.World journal of gastroenterology · 2010Pooled it
- Management of intraductal papillary mucinous neoplasms.Current gastroenterology reports · 2008Pooled it
- Highly Accurate Identification of Cystic Precursor Lesions of Pancreatic Cancer Through Targeted Mass Spectrometry: A Phase IIc Diagnostic Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Trial
- Clinico-pathological features and prognosis of mixed-IPMNs with a focal involvement of the main pancreatic duct.Updates in surgery · 2026Article
- Advances in IPMN imaging: deep learning-enhanced HASTE improves lesion assessment.European radiology · 2026Article
- Misdiagnosis of pancreatic intraductal papillary mucinous neoplasms and the challenge of mimicking lesions: imaging diagnosis and differentiation strategies.Abdominal radiology (New York) · 2025Review
- Review
- The spearfishing sign: differentiating mucin from mural nodules in pancreatic cysts.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2023Article
- Cystic Neoplasms of the Pancreas: Differential Diagnosis and Radiology Correlation.Frontiers in oncology · 2022Review
- Pearls and pitfalls of imaging features of pancreatic cystic lesions: a case-based approach with imaging-pathologic correlation.Japanese journal of radiology · 2021Review
- Article
- Differentiating benign from malignant pancreatic cysts on computed tomography.European journal of radiology open · 2020Article
- Comparative Effectiveness of Resection vs Surveillance for Pancreatic Branch Duct Intraductal Papillary Mucinous Neoplasms With Worrisome Features.JAMA surgery · 2018Review
- Article
- Natural courses of branch duct intraductal papillary mucinous neoplasm.Langenbeck's archives of surgery · 2017Article
- Are Clinical Guidelines for the Management of Intraductal Papillary Mucinous Neoplasms Followed?: A Single-Center Analysis.Pancreas · 2017Article
- Article
28 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBranch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) of the pancreas are reported to be less aggressive than the main-duct type. Hence, less aggressive treatment has been proposed for the former.
aimTo evaluate the effectiveness of a follow-up protocol for BD-IPMNs.
designProspective study.
settingAn academic tertiary referral centre. PATIENTS: From 2000 to 2003, 109 patients with BD-IPMNs underwent trans-abdominal ultrasound and magnetic resonance cholangiopancreatography with secretin. Patients who presented malignancy-related parameters (size >3.5 cm, nodules, thick walls, carbohydrate antigen 19.9 level >25 U/l, recent-onset or worsened diabetes) and/or complained of symptoms were submitted to surgery (arm A). All asymptomatic patients without suspicion of malignancy were followed up according to a 6-month clinical-radiological protocol (arm B).
main outcome measuresThe effectiveness of conservative management of BD-IPMNs.
results20 (18.3%) patients underwent surgery (arm A); pathological diagnosis of BD-IPMNs was always confirmed. 89 (81.7%) patients were followed up for a median of 32 months (arm B); of these, 57 (64%) patients had multifocal disease. After a mean follow-up of 18.2 months, 5 (5.6%) patients showed an increase in lesion size and underwent surgery. The pathological diagnosis was branch-duct adenoma in three patients and borderline adenoma in two.
conclusionsSurgery is indicated in <20% of cases of BD-IPMNs, and, in the absence of malignancy-related parameters, careful non-operative management seems to be safe and effective in asymptomatic patients. Although observation for a longer time is needed to confirm these results, our findings support the guidelines recently recommended by the International Association of Pancreatology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.