ArticleBiochemical and biophysical research communications2007
A novel model to identify interaction partners of the PTEN tumor suppressor gene in human bladder cancer.
Article in Biochemical and biophysical research communications, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Transcriptome-(phospho)proteome characterization of brain of a germline model of cytoplasmic-predominant Pten expression with autism-like phenotypes.NPJ genomic medicine · 2021Article
- Phosphatase and Tensin Homolog (PTEN) Represses Colon Cancer Progression through Inhibiting Paxillin Transcription via PI3K/AKT/NF-κB Pathway.The Journal of biological chemistry · 2015Article
- PTEN function: the long and the short of it.Trends in biochemical sciences · 2014Review
- Phosphatase and tensin homologue deleted on chromosome 10.Nigerian medical journal : journal of the Nigeria Medical Association · 2013Article
- Effects of indomethacin on expression of PTEN tumour suppressor in human cancers.Nigerian medical journal : journal of the Nigeria Medical Association · 2013Article
- TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals.Haematologica · 2010Article
- Development of a multiplex quantitative PCR signature to predict progression in non-muscle-invasive bladder cancer.Cancer research · 2009Article
- ced-4 and proto-oncogene tfg-1 antagonistically regulate cell size and apoptosis in C. elegans.Current biology : CB · 2008Article
- NHERFs, NEP, MAGUKs, and more: interactions that regulate PTEN.Journal of cellular biochemistry · 2007Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Phosphatase and tensin homolog (PTEN), deleted on chromosome 10, is a potent tumor suppressor. PTEN expression is reduced in advanced bladder cancer and reduction correlates with disease stage. To gain insights into the function of PTEN in human bladder cancer by identifying its binding partners, we developed a novel IPTG inducible PTEN expression system and evaluated this system in the PTEN null UMUC-3 human bladder cancer xenograft model. In this model, induction of PTEN in vivo resulted in reduced tumor growth. We used mass spectrometry to identify PTEN interaction partners in these cells, which identified known interaction partners major vault protein (MVP) and paxillin as well as a novel interaction partner, TRK fused gene (TFG). In conclusion, using a biologically relevant model system to dissect PTEN tumor suppressor function in human bladder cancer, we identified three molecules important for many cellular functions in complex with PTEN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.