ArticleGenomics2007
Allele-specific histone modifications regulate expression of the Dlk1-Gtl2 imprinted domain.
Article in Genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 72 citations in OpenAlex.
- Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage.Nature communications · 2022Article
- Global miRNA/proteomic analyses identify miRNAs at 14q32 and 3p21, which contribute to features of chronic iron-exposed fallopian tube epithelial cells.Scientific reports · 2021Article
- Role of genomic imprinting in mammalian development.Journal of biosciences · 2020Review
- MicroRNAs in Cardiac Diseases.Cells · 2019Review
- Identification of the novel Ido1 imprinted locus and its potential epigenetic role in pregnancy loss.Human molecular genetics · 2019Article
- The Dysregulation of theDiabetes · 2018Article
- A Hearty Dose of Noncoding RNAs: The ImprintedJournal of cardiovascular development and disease · 2018Review
- Transgenerational Effects of Bisphenol A on Gene Expression and DNA Methylation of Imprinted Genes in Brain.Endocrinology · 2018Article
- Genetic compensation: A phenomenon in search of mechanisms.PLoS genetics · 2017Review
- Expression and imprinting of DIO3 and DIO3OS genes in Holstein cattle.Journal of genetics · 2017Article
- Perspective: Is Random Monoallelic Expression a Contributor to Phenotypic Variability of Autosomal Dominant Disorders?Frontiers in genetics · 2017Article
- Delta-like 1 homolog in Capra hircus: molecular characteristics, expression pattern and phylogeny.Molecular biology reports · 2016Article
- Kagami-Ogata syndrome: a clinically recognizable upd(14)pat and related disorder affecting the chromosome 14q32.2 imprinted region.Journal of human genetics · 2016Review
- The Upregulation of Genomic Imprinted DLK1-Dio3 miRNAs in Murine Lupus Is Associated with Global DNA Hypomethylation.PloS one · 2016Article
- TRIM28 Controls Genomic Imprinting through Distinct Mechanisms during and after Early Genome-wide Reprogramming.Cell reports · 2015Article
- Molecular insights into transgenerational non-genetic inheritance of acquired behaviours.Nature reviews. Genetics · 2015Review
- Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct.Molecules and cells · 2015Article
- Non-germ Line Restoration of Genomic Imprinting for a Small Subset of Imprinted Genes in Ubiquitin-like PHD and RING Finger Domain-Containing 1 (Uhrf1) Null Mouse Embryonic Stem Cells.The Journal of biological chemistry · 2015Article
- Genome-wide high resolution parental-specific DNA and histone methylation maps uncover patterns of imprinting regulation in maize.Genome research · 2014Article
- Regulation of Mammalian Gene Dosage by Long Noncoding RNAs.Biomolecules · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Dlk1 and Gtl2 are reciprocally expressed imprinted genes located on mouse chromosome 12. The Dlk1-Gtl2 locus carries three differentially methylated regions (DMRs), which are methylated only on the paternal allele. Of these, the intergenic (IG) DMR, located 12 kb upstream of Gtl2, is required for proper imprinting of linked genes on the maternal chromosome, while the Gtl2 DMR, located across the promoter of the Gtl2 gene, is implicated in imprinting on both parental chromosomes. In addition to DNA methylation, modification of histone proteins is also an important regulator of imprinted gene expression. Chromatin immunoprecipitation was therefore used to examine the pattern of histone modifications across the IG and Gtl2 DMRs. The data show maternal-specific histone acetylation at the Gtl2 DMR, but not at the IG DMR. In contrast, only low levels of histone methylation were observed throughout the region, and there was no difference between the two parental alleles. An existing mouse line carrying a deletion/insertion upstream of Gtl2 is unable to imprint the Dlk1-Gtl2 locus properly and demonstrates loss of allele-specific methylation at the Gtl2 DMR. Further analysis of these animals now shows that the loss of allele-specific methylation is accompanied by increased paternal histone acetylation at the Gtl2 DMR, with the activated paternal allele adopting a maternal acetylation pattern. These data indicate that interactions between DNA methylation and histone acetylation are involved in regulating the imprinting of the Dlk1-Gtl2 locus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.